This $986,486.00 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The primary goal of this 5-year project, awarded on May 6, 2025, is to discover new synthetic strategies and concepts to rapidly prepare biologically important and structurally complex molecules, particularly natural products from the Euphorbiaceae and Thymelaeaceae plant families. The research aims to...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $800,308 to the University of Wisconsin-Madison to conduct research on engineering promiscuous enzymes for the synthesis of biological building blocks. The research aims to analyze the structure, kinetics, and spectroscopy of a suite of pyridoxal-phosphate dependent enzymes that can catalyze C-C bond forming reactions, and to...
The University of Washington was awarded a $500,000 Project Grant from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support research titled "NEW CATALYTIC TRANSFORMATIONS FOR THE SYNTHESIS OF ALKENES AND ORGANOBORON COMPOUNDS" from July 15, 2021 to June 30, 2024. The grant funding will support the University's research efforts to advance the synthesis of alkenes and organoboron compounds...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $360,100 to The Regents of the University of California, Berkeley (UC Berkeley) to conduct research on supramolecular catalysis for pharmaceutical applications. The project aims to develop innovative synthetic methods leveraging supramolecular hosts to enable transformations relevant to the production of pharmaceuticals,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is focused on developing new reactions and reagents to generate enantioenriched organic compounds. The $422,569 award supports research aimed at the concise synthesis of secondary amines, tertiary amines, and vicinal diamines as single stereoisomers. The proposed methods involve the use of bis(amidine) reagents that form chiral...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,793,116.00 in funding to the University of Wisconsin - Madison for a research project titled "Harnessing Divergent Reactivities of Unusual Reactive Intermediates as Platforms to Explore High Fsp3 Amine Chemical Space." The project aims to develop innovative synthetic methods to rapidly transform simple precursors...
This Project Grant award, valued at $775,000.00 and made by the National Institute of General Medical Sciences (NIGMS), supports research under the Biomedical Research and Research Training Program (CFDA 93.859) to expand the chemical and functional space using boron-nitrogen heterocycles. The key objectives of this 5-year project are to: 1) explore novel reactivity and selectivity in synthetic organic chemistry using boron-containing compounds, and discover new mechanistic principles for...
This $1,542,569 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is funding the development of new copper-catalyzed chemical reactions to enable the efficient and stereoselective synthesis of chiral amine derivatives and ethers, including saturated heterocycles. The research objectives include exploring reactions for propagating chirality, developing new enantioselective syntheses of...
This $300,000 Project Grant award from the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) supports Professor Gojko Lalic at the University of Washington in the development of new chemical reactions for organic synthesis using organoboron compounds and transition metal catalysis. The research aims to create more efficient methods for constructing carbon-carbon bonds, which are critical for the synthesis of complex...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $146,816 to support research on the biocatalytic synthesis of N-N and C-N heterobiaryl atropisomers. The award to the Regents of the University of Michigan aims to develop general strategies for the synthesis of these medicinally relevant atropisomers, which have demonstrated potential for improved drug potency, selectivity, and...