The University of Wisconsin System has been awarded a $800,308 Project Grant from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) to conduct research on engineering promiscuous enzymes for the synthesis of biological building blocks.
The key objectives of this 5-year grant, awarded on August 15, 2024, are to: 1) perform mechanistic analysis of a suite of pyridoxal-phosphate dependent enzymes that catalyze standalone...
This $495,117 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to uncover the hidden biosynthetic capabilities of fungi. The key product deliverables under this 5-year grant include:
(1) Elucidating the biosynthetic pathways and chemical structures of natural products containing the unusual isocyanide functional group produced by fungal microorganisms.
(2)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $390,000.00 over a 5-year period from August 1, 2024 to May 31, 2029 to the University of Texas at Dallas. The award supports research focused on developing new catalytic stereoselective methods to generate densely substituted polycyclic building blocks, designing new synthesis logics to enable the preparation of complex...
This $369,199 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of North Carolina at Wilmington to develop novel stereoselective methods for the synthesis of biologically-active nitrogen-containing small molecules. The key objectives are to: 1) produce single enantiomer amine derivatives through enantioselective aziridine opening with enolate equivalents, and...
This $146,816 Project Grant awarded on May 13, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop general strategies for the synthesis of N-N and C-N heterobiaryl atropisomers. The principal investigator will employ bioinformatic techniques to develop a library of flavin-dependent aromatic hydroxylase (FDAH) enzymes and explore their unique coupling reactivity to identify...
This $125,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the California Institute of Technology (Caltech) with two key objectives:
Establishing the first total syntheses of the bacterial metabolites azetidomonamide A, azetidopyridone, and diazetidomonapyridone to enable their biological evaluation, as these compounds are known to affect biofilm formation...
This Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to expand the metabolic currencies of life for the development of natural product-derived medicines. The $1,111,812 grant, awarded on June 1, 2024, aims to develop methods to improve the efficiency of an unnatural cofactor technology, making it easier to adopt by the bioengineering community. The research also...
The National Institute of General Medical Sciences (NIGMS) awarded a $710,000 Project Grant to The University of Texas at San Antonio under the Biomedical Research and Research Training program (CFDA 93.859). This 5-year grant, running from July 1, 2024 to April 30, 2029, will fund research to develop new sulfinate-based synthetic methodologies for efficiently constructing carbon-heteroatom and carbon-carbon bonds. The research aims to advance organic synthesis and medicinal chemistry by...
This $385,000 five-year Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) aims to develop new chemical methods for the practical synthesis of bioactive cyclic and lasso peptide scaffolds. The University of Utah will lead this research, which has two primary objectives: 1) Develop strategies to prepare cyclic/bicyclic peptides as potential antimicrobial therapeutic leads, particularly against...
This $549,359 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the Chemistry-Biology Interface Training (CBIT) program at the University of Wisconsin - Madison. The CBIT program aims to provide cross-disciplinary research training to graduate students, enabling chemists and biologists to develop a deeper understanding and application of each other's tools and techniques. Key features of...