Investigating and manipulating cells in low oxygen environments using lipid nanoparticles
Active Project Grant Awarded Last action
- Award ID
- R35GM157060
- Recipient
-
University Of North Carolina At Chapel Hill UEI D3LHU66KBLD5 Part of University Of North Carolina System Office
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,871,776
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 37% complete
- Place of performance
- Chapel Hill, NC 27599, USA
Award details come from USAspending.gov.
Description
- Abstract
- Low oxygen environments (loes) are a common characteristic of numerous physiologically relevant conditions in many different locations in the body. Accordingly, understanding how loes impact the cellular response to technologies that can investigate and manipulate cells is an essential area of fundamental research that can lay the foundation for advancing health. Recently, lipid nanoparticles (lnps) have emerged as promising technologies that can investigate and manipulate cells using messenger RNA (mrna). Studies investigating the impact of LOE on mrna LNP are currently limited, and addressing this key GAP in our knowledge will be essential for understanding how to best investigate and manipulate cells in LOE using mrna lnps. Here, we will address this key GAP in knowledge by studying two overarching research areas - mechanism (research area 1) and tool development (research area 2). In mechanism, we will perform comparative analyses exploring how various states of LOE impact the cellular uptake mechanisms of mrna lnps across different cell types, mrna sequences, and LNP types. In tool development, we will develop low oxygen environment nanoparticles (loenrs), a novel class of tools for better investigating and manipulating cells under LOE. This research will be performed in my laboratory at UNC, an environment that strives to train the next generation of scientific leaders in a diverse and inclusive environment. In undertaking this approach, we hope our research will provide key fundamental insights about how cells respond to LOE, a common characteristic of physiologically relevant conditions that arise in many different locations in the body.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $38,199 | |
| Amendment | $343,796 | |
| Amendment | $343,796 | |
| Amendment | $381,995 | |
| Amendment | $381,995 | |
| Original award | $381,995 |
Quick answers
Who received award R35GM157060?
R35GM157060 was awarded to University Of North Carolina At Chapel Hill by National Institute of General Medical Sciences (National Institutes of Health) on January 1, 2025.
How much is award R35GM157060 worth?
$1,871,776 has been obligated on R35GM157060.
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