This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $372,100 to the University of Wisconsin - Madison to develop novel "mechanoimaging" technologies that can measure and program piconewton-scale mechanical forces exerted by individual cell receptors in viscoelastic biomaterials. The goal is to quantify how cells, including fibroblasts, cancer cells, and T cells, physically remodel and interact with viscoelastic extracellular matrices, which is critical for understanding processes like cancer metastasis, immune function, and wound healing. Additionally, the project aims to engineer cells to exert strong forces in viscoelastic environments, which could have implications for improving cancer immunotherapies. The 5-year award period runs from February 1, 2025 to January 31, 2030.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $372.1k | 1/1/25 |