This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will provide $392,500.00 to Arizona State University (ASU) over a five-year period from January 1, 2025 to December 31, 2029. The funding will support research aimed at identifying predictive rules for cross-species viral transmission from wild mammals to humans, particularly in relation to recent zoonotic disease outbreaks like Ebola,...
The National Institute of General Medical Sciences (NIGMS) has awarded a $2,070,444 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to conduct research on the genetic and evolutionary determinants of population variation in transcriptional responses to pathogens. The 5-year project aims to explore the effects of natural selection and genetic ancestry on gene expression, epigenetic traits, and immune responses to infection across diverse...
This five-year, $490,536 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research and education activities to understand how genetic and ecological sources of variation affect host-pathogen dynamics. The principal investigator will conduct field and laboratory experiments to determine how intraspecific variation in pathogen life history traits and host susceptibility influence outcomes of pathogen strain competition and long-term...
This $388,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to better understand how the joint effects of selection and other evolutionary processes shape patterns of genomic variation. The research aims to generate improved estimates of the genome-wide fitness effects of new mutations, understand how selection against deleterious mutations affects variation in self-fertilizing...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,192,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Pittsburgh to support research into how human-relevant biology evolved through the capture of viral genes by our distant ancestors. The key objectives are to: Leverage expertise in evolutionary biology, protein biochemistry, and B cell immunology to generate and disseminate high-quality reagents for studying endogenous...
This $346,582 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of novel statistical and computational methods for genetic epidemiology. The key products and services to be delivered include: Efficient coalescent-based phylodynamic methods to jointly infer genealogies and model parameters from pathogen genetic data, incorporating realistic biological...
This $1,108,345 federal Project Grant award, funded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), supports research to characterize the evolutionary transition of host-microbe interactions from commensal symbionts to blood parasites in apicomplexan organisms, which include the parasites that cause malaria. The project, led by the University of Rhode Island, will use advanced microscopy and genomics to compare the cellular invasion machinery between...
The National Institute of General Medical Sciences (NIGMS) awarded a $216,906 Project Grant to The Regents of the University of Colorado, doing business as the University of Colorado Office of Contracts and Grants Division, to conduct research on the "Evolution of Novel Metabolic Pathways" under CFDA Program 93.859 - Biomedical Research and Research Training. The funding will support the University's efforts to study how organisms can evolve new metabolic pathways to access new...
The National Institute of General Medical Sciences (NIGMS) awarded Oregon State University a 5-year, $1,048,663 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research aimed at understanding the factors underlying variation in complex organismal traits. The research will use experimental evolution and molecular phenotyping approaches with fruit fly populations to study the genetic and physiological mechanisms underlying differences in aging,...
The National Institute of General Medical Sciences (NIGMS) awarded a $463,157 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of California, Berkeley, with a subcontract to the University of Oregon. The objective is to measure and model how antimicrobial resistance (AMR) evolution depends on the self-organization of bacterial populations, ranging from microscale biofilms to gut-lumen distributed populations. The project will use...