This federal Project Grant award of $2,025,831 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports advanced research on the molecular mechanisms of eukaryotic chromosome replication. The grant aims to illuminate both the intrinsic functioning of the eukaryotic DNA replication machinery and its response to various replication stress conditions that can lead to genome instability and diseases like...
The National Institute of General Medical Sciences (NIGMS) awarded a $427,571 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The award, which runs from January 15, 2025 to December 31, 2029, will support research to uncover the molecular determinants of cellular identity and the regulation of chromatin states across the cell cycle. Specifically, the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $254,919 to the University of California, San Diego (UCSD) over a 5-year period from February 1, 2025 to January 31, 2030. The award supports research to understand the regulatory mechanisms that ensure accurate transmission of the genome during cell division. Key focus areas include investigating how cells prevent incomplete DNA...
This $2,285,694 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at Tufts University to study the relationship between DNA replication and tandem repeat instability. The grantee will combine genetic assays and single-cell live microscopy analysis in a model system to understand how repeat length changes during replication. This dual approach will examine how a repeat's length, propensity to form DNA structures, and orientation...
This Project Grant award of $289,856 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research by Yale University to elucidate the molecular and structural mechanisms of metazoan origin licensing. The research aims to determine how metazoan MCM loading intermediates mature into MCM double hexamers through various licensing pathways, how these pathways have evolved across multicellular eukaryotes, and how...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $438,629.00 to the University of Massachusetts to investigate the fundamental mechano-molecular mechanisms of cell division. The project aims to characterize the functional contributions of large intrinsically disordered protein regions at the kinetochore and perichromosomal layer, as well as study the regulation...
This Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program provides $900,000 to The Regents of the University of Colorado (CU) to conduct research on the molecular mechanisms underlying the DNA methyltransferase 1 (DNMT1) enzyme's role in inheritance of gene silencing. The project aims to utilize structural biology, biochemistry, and cell biology methods to understand DNMT1 regulation and the mechanism cells use to restrict DNMT1...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,125,461 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Illinois in Urbana, IL. The grant will fund a 5-year research project focused on understanding the role of the Origin Recognition Complex (ORC) and its subunits in regulating DNA replication, DNA damage response, and chromatin organization. The research aims to elucidate the biochemical functions of the ORC6...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,443,286 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation For The State University Of New York (RF SUNY). The grant, effective September 16, 2024 through June 30, 2029, will support research to characterize the role of elevated deoxyribonucleotide triphosphate (dNTP) pools in sensitizing the DNA replication machinery, known as the replisome. The research aims...
The National Institute of General Medical Sciences (NIGMS) awarded a $445,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Dana-Farber Cancer Institute, Inc. (Dfci) in Boston, Massachusetts. The grant, which runs from January 22, 2025 to December 31, 2029, supports research to elucidate the molecular mechanisms of DNA double-strand break repair by homologous recombination. The goal of this project is to define the processes that allow cells to...