Evolutionary and functional genomics of genetic novelties and expression adaptation in drosophila - adaptive transcriptome evolution likely underlies a substantial component of all adaptations
Active Project Grant Awarded Last action
- Award ID
- R35GM156525
- Recipient
-
University Of California, Davis UEI TX2DAGQPENZ5
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,918,214
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 35% complete
- Place of performance
- Davis, CA, USA
Award details come from USAspending.gov.
Description
Here i propose to study two main types of transcriptome evolution using drosophila. First, we will identify transcriptome novelties in drosophila melanogaster, focusing on reproductive tissues. We will then investigate the functions of these novelties using crispr and rnai to learn about the possible agents of selection acting on them. Second, we will investigate convergent local adaptation at the transcriptome level in two distantly related species, d. Simulans and d.hydei, and identify the underlying regulatory basis to determine whether convergent expression adaptation has a shared genetic basis or whether IT generally proceeds by different trajectories in different species. Finally, we will carry out a more general investigation of the role of directional selection in driving expression divergence between drosophila species.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $10,514 | |
| Amendment | $48,300 | |
| Amendment | $48,300 | |
| Amendment | $434,700 | |
| Amendment | $434,700 | |
| Amendment | $434,700 | |
| Original award | $507,000 |
Quick answers
Who received award R35GM156525?
R35GM156525 was awarded to University Of California, Davis by National Institute of General Medical Sciences (National Institutes of Health) on January 10, 2025.
How much is award R35GM156525 worth?
$1,918,214 has been obligated on R35GM156525.
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