Project Grant R35GM156358

Award Date 4/15/25
Completion Date 3/31/30
Dollars Obligated $660K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Storrs, CT 06269, USA
Similar Awards
The National Science Foundation (NSF) awarded a $802,161 Project Grant to the University of Massachusetts Medical School (UMass Medical) to study the structural mechanisms of bacteriophage (phage) infection and assembly. This 3-year grant, effective June 1, 2024, aims to advance the understanding of virus-host interactions, promote the development of effective antiviral strategies, and leverage phage-related applications. The research will focus on three aspects of the phage life cycle: virus...
This federal Project Grant award, funded by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074), aims to advance the fundamental understanding of how viruses self-assemble and replicate within host cells. The $987,566 award, granted on December 15, 2024, supports a collaborative research project between investigators in the U.S. and France to elucidate the differences between in vitro and in cellulo viral processes. The research will progressively add molecules that...
This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $219,117 to San Diego State University Foundation to investigate how RNA genomes of bacteriophages (viruses that infect bacteria) are packaged into their protein capsids. The 5-year project aims to identify the key RNA structures involved in the selective packaging of viral RNA, which will advance the understanding of RNA bacteriophage diversity and enable the production...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $729,010 to Texas A&M University to conduct research on novel phage lysis proteins. The project aims to experimentally characterize the mechanisms of action used by phage to lyse bacterial cells, with a focus on identifying and studying divergent lysis protein strategies in E. coli and gut microbiome phages. The research...
This Project Grant award of $370,086 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to leverage single-molecule microscopy techniques to gain molecular-level insights into the structure, assembly, and dynamics of bacterial type IV pili (TFP) systems. The principal investigator at Texas A&M University will use super-resolution microscopy and single-molecule FRET to: 1) map the precise locations and...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $375,430.00 to the University of Wisconsin System for a research program focused on understanding how viral pathogens hijack host DNA replication and repair machinery. The research aims to reveal the mechanisms by which viruses dysregulate cellular DNA repair and replication pathways, which is critical for developing therapeutic interventions. Key...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $430,613 to the University of Maine System to investigate the role of phosphoinositides in influenza virus assembly. The research aims to understand how the viral hemagglutinin protein forms clusters and co-clusters with the matrix protein M1 in the host cell membrane, and the involvement of host cell...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research by New York University (NYU) to investigate the role of biomolecular condensates in bacterial adaptation and evolution. The $402,500 award, spanning Sep 2024 to Jul 2029, aims to develop novel microscopy techniques to study the structure, dynamics, and interactome of bacterial condensates. The research seeks to...
This Project Grant award of $441,250 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support a 5-year research project at the University of Washington to investigate regulators of bacterial chromosome organization. The key objectives are to: 1) elucidate the mechanism of the GAPR protein, which regulates DNA supercoiling and topoisomerase activity, as a model for understanding how bacteria and bacteriophages...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA #93.859 Biomedical Research and Research Training, will support a research program focused on studying the functional convergence at the host-virus interface. Key objectives include: Performing structural homology searches to define patterns of gene capture in diverse viruses and identify structural homologs of antiviral proteins in diverse metazoan species. Investigating the independent...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $659,949 to the University of Connecticut (UConn) to conduct research on bacteriophage P22, a model system for understanding the molecular mechanisms of viral capsid assembly and virus-host interactions. The key objectives are: 1) Reveal how the scaffolding protein interacts with capsid proteins to control proper assembly of procapsids; 2) Understand the scaffolding protein structure and arrangement within procapsids; and 3) Investigate the signaling process that leads to scaffolding protein exit and capsid maturation during DNA packaging. The project will also study underexplored systems in P22's interaction with host cells, including the mechanism of superinfection exclusion and the function of the P22 gp14 protein. The research will leverage a combination of molecular biology, genetics, omics approaches, biochemistry, and structural analyses. The award has an initial term from April 2025 through March 2030.

Generated 4/29/25, 3:17 AM