Project Grant R35GM156263
- This federal Project Grant award, valued at $427,625.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the conformational dynamics and regulatory mechanisms of the KCNH family of ion channels. The research aims to examine the voltage sensor domain and S4 helix of KCNH channels to measure their structural changes during channel opening and closing. The project will...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- This federal Project Grant award of $534,160.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The research aims to elucidate the mechanisms by which ions are recognized and transported across membranes, how the...
- This Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $437,709 award supports research to better understand the biophysical mechanisms underlying the generation of inward and outward curvature in cellular membranes. This research aims to elucidate the role of lipid bilayer interactions with the cytoskeleton and extracellular glycocalyx in controlling membrane bending...
- This federal Project Grant award of $329,976 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to establish a multiscale modeling strategy to simulate ion selectivity in proteins. The principal investigator will utilize novel force fields to conduct molecular dynamics simulations that provide structural, dynamic, and thermodynamic insights into protein-ion interactions. The research aims to analyze the...
- This federal Project Grant award, valued at $383,008, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The purpose of the grant is to conduct computational studies on the molecular mechanisms underlying various mutations in voltage-gated sodium (NaV) channels, which are associated with a broad spectrum of channelopathies including epilepsy, autism, and cardiac arrhythmias. The research aims to...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $400,530 Project Grant to the Rector & Visitors of the University of Virginia (UVA) on June 1, 2025. The grant supports UVA's research to develop next-generation nanodisc tools that can characterize membrane protein-lipid interactions essential for understanding cell-cell interactions and communication. Specifically, the research will focus on...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $410,601 to the University of Florida to investigate the molecular mechanisms underlying the regulation of the TRPM3 ion channel in the cell membrane. The key objectives are to: 1) determine the structures and activities of individual TRPM3 channels in isolation and in cell membranes to understand the molecular...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
- This federal Project Grant award of $398,444, awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to systematically dissect the contributions of the cellular environment on the polymodal regulation of transient receptor potential (TRP) ion channels. The University of Texas at San Antonio (UTSA) will conduct cell-based experiments and in vitro reconstitution...
This $576,104 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental research on the molecular mechanisms underlying transmembrane conduction and signaling in integral membrane proteins. The research aims to define the structural transitions and energy coupling processes that drive and regulate cyclical processes in membrane proteins, with a focus on understanding voltage sensing domains and their role in regulating voltage-gated ion channels. The project will utilize carefully selected intracellular voltage-gated ion channels, including two-pore channels and a hyperpolarization-activated channel, to investigate these mechanisms. The award was made on August 15, 2025 and has an ultimate completion date of July 31, 2030. The grant recipient is The Regents of the University of California, San Francisco, a prominent academic medical center and research institution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $576.1k | 8/7/25 |