The National Institute of General Medical Sciences (NIGMS) awarded a $440,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research in New York. The 5-year grant, awarded on February 3, 2025, supports advanced research to decode the ubiquitin and autophagy signaling networks, which are essential cellular processes involved in proteome homeostasis. The research program combines expertise in quantitative mass spectrometry,...
The National Institute of General Medical Sciences (NIGMS) awarded a $627,797 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Cornell University, effective May 1, 2025 through April 30, 2030. The goal of this research program is to delineate the inner workings of membrane-associated protein complexes that shape the form and function of tissues, and whose dysfunction leads to serious human diseases. The research leverages a multi-disciplinary approach...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), will fund research to identify and characterize a novel family of GTPase Activating Proteins (GAPs). The $226,608 award to Cornell University will support two specific aims: 1) Using genetic and live-cell imaging techniques to determine the target substrates and subcellular localization of these novel GAPs, and 2)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $528,129 to the University of Connecticut Health Center to conduct research on the ubiquitin-proteasome pathway and its role in human disease. The key objectives of this 5-year research program are to: Structurally and functionally characterize critical ubiquitinating and de-ubiquitinating enzymes implicated in human...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $467,599 in funding to Syracuse University to conduct research on the architecture and function of ubiquitin-binding biomolecular condensates and their role in protein quality control. The 5-year research program aims to achieve a mechanistic understanding of how ubiquitin-binding shuttle proteins regulate the assembly, structure, and...
The National Institute of General Medical Sciences (NIGMS) has awarded a $365,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Montclair State University. The grant will fund research to study the structural mechanism of spontaneous ubiquitin cargo clustering on the cell plasma membrane. The principal investigator will use fluorescence microscopy and atomic force microscopy techniques to identify the structural organization of ubiquitin cargo...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $659,230.00 to Cornell University over the period of September 1, 2024 to June 30, 2028. The grant supports research to define how the CymA protein in the gram-negative bacterium Shewanella oneidensis coordinates spatially and temporally with its redox partners to mediate efficient extracellular electron transfer (EET)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund research to characterize the molecular mechanisms and evolution of cyclic diguanylic acid (c-di-GMP) signaling in the antibiotic-producing bacterial genus Streptomyces. The $383,746 award, with a performance period from January 1, 2025 to December 31, 2029, will be executed by Cornell University's Office of Sponsored...
This federal Project Grant award of $428,202 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on the mechanisms that generate robustness in organ size and shape during plant development. The awardee, Cornell University, will focus on three key areas: (1) understanding how stochasticity in hormone signaling is buffered during organ initiation, (2) elucidating how organ growth is robust to...
The National Institute of General Medical Sciences (NIGMS) awarded a $153,656 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Fred Hutchinson Cancer Center in Seattle, WA. The funding supports research to understand how post-translational modifications, specifically ubiquitin, contribute to kinetochore assembly and function in the budding yeast Saccharomyces cerevisiae. The research aims to generate a comprehensive map of kinetochore regulation by...