Catalytic c-c coupling via hydrogen transfer
Active Project Grant Awarded Last action
- Award ID
- R35GM155947
- Recipient
-
University Of Texas At Austin UEI V6AFQPN18437 Part of University Of Texas System
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,950,890
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 35% complete
- Place of performance
- Austin, TX 78759, USA
Award details come from USAspending.gov.
Description
- Abstract
- Catalytic hydrogenations are the most frequently utilized chemical reactions in the synthesis of pharmaceutical ingredients, constituting 14% of GMP reactions (oxidations = 3% of GMP reactions). Metal-catalyzed cross-coupling and carbonyl addition are the most frequently utilized methods for c-c bond formation among GMP reactions. We seek to develop a family of catalytic methods for c=x/c=c (x = o, NR) and c-x/c-y (x = y = halide) reductive c-c couplings mediated by H2, 2-proh, NAO2CH that are as clean, scalable and cost-effective as catalytic hydrogenation. This includes catalytic hydrogen auto-transfer reactions that affect direct conversion of lower alcohols/amines to higher alcohols/amines via CH-XH/c=c (x = o, NR) c-c coupling. These methods inform parallel studies on the total synthesis of polyketide natural products with anti-cancer or anti-bacterial properties. Under the NIH-mira program, our work on catalysis (R01 GM069445) and total synthesis (RO1 GM093905) will be integrated to maximize their synergy.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $59,264 | |
| Amendment | $533,383 | |
| Amendment | $533,383 | |
| Amendment | $40,340 | |
| Amendment | $40,340 | |
| Amendment | $40,340 | |
| Amendment | $425,960 | |
| Amendment | $425,960 | |
| Amendment | $425,960 | |
| Original award | $425,960 |
Quick answers
Who received award R35GM155947?
R35GM155947 was awarded to University Of Texas At Austin by National Institute of General Medical Sciences (National Institutes of Health) on February 1, 2025.
How much is award R35GM155947 worth?
$2,950,890 has been obligated on R35GM155947.
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