This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop complementary biotherapeutic delivery platforms to enable re-delivery of adeno-associated virus (AAV) gene therapies. The $1,095,274 award, with a performance period from August 1, 2024 to May 31, 2029, focuses on three key delivery platforms: 1) Targeted cell delivery of regulatory T cells to immunogenic cell death sites; 2) Targeted delivery of IgG-degrading protease to selectively remove neutralizing antibodies against AAV vectors; and 3) Targeted lipid nanoparticles for cell-specific RNA delivery to induce tolerogenic antigen processing. By addressing key biological barriers to AAV re-delivery, this research seeks to enable transformative advancements in gene therapy and improved human health.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $385.7k | 5/30/25 | ||
| Not listed | $354.8k | 7/12/24 | ||
| Not listed | $354.8k | 7/12/24 |