This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $1,117,746.00 to the University of Miami to develop innovative drug delivery strategies. The project aims to engineer prodrugs with improved pharmacokinetics, biodistribution, and therapeutic efficacy to address limitations of small molecule drugs. Key approaches include designing albumin-binding targeted prodrugs and responsive...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a novel computational platform for discovering non-ribosomal peptide natural products. The $781,502 award to Chemia Biosciences, Inc., a small disadvantaged business in Pittsburgh, PA, aims to create efficient and accurate methods for identifying new natural product small molecules from complex mass...
This $456,977 project grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to elucidate the membrane properties regulating antimicrobial peptide binding to bacterial outer membrane vesicles (OMVs). The research will leverage innovative approaches to study protein-lipid interactions at the single-vesicle and subpopulation levels, in order to uncover the specific OMV characteristics that influence...
This Project Grant award of $350,000.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop an artificial intelligence-based platform for optimizing peptide-based drug candidates. The key products or services to be delivered include: Methods for encoding non-canonical amino acids and cyclic peptides to enable high-performance machine learning on commercial peptide sequence, activity, stability, and...
The National Institute of General Medical Sciences (NIGMS) awarded a $384,896 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Missouri System. The award will fund research to engineer peptide-based biomodulatory materials that can serve as translational platform technologies for various biomedical applications. Specific objectives include using computational and experimental techniques to develop design rules for micellar...
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
This $1,549,956 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program supports research at The Ohio State University to understand the role of the O-GlcNAc Transferase (OGT) enzyme in host defense mechanisms against viral and bacterial infections. The research aims to elucidate how OGT senses pathogen infection and integrates innate immune signaling and cellular lipid metabolism through both...
This federal Project Grant award of $597,573 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports structural and dynamic studies of large protein and protein-nucleic acid complexes and assemblies that play key roles in human health and disease. The primary objectives are to: (1) provide atomic-resolution insights into the structure, dynamics, interactions, and function of nucleosomes and large nucleosome arrays...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $1,144,714 to the University of Illinois to conduct research aimed at discovering novel antibiotics for gram-negative pathogens. The primary goals are to identify physicochemical traits that allow antibiotics to evade efflux pumps in E. coli, P. aeruginosa, and A. baumannii, and then apply this knowledge to develop at...
The National Institute of General Medical Sciences (NIGMS) awarded a $402,500 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The grant, which runs from January 1, 2025 to November 30, 2029, aims to develop synthetic biology tools and strategies to streamline the engineering of bacterial theragnostic systems that can sense and respond to specific disease...