Understanding the role of the nuclear pore complex in undifferentiated cell proliferation and gene gating
Active Project Grant Awarded Last action
- Award ID
- R35GM154623
- Recipient
-
The Regents Of The University Of California UEI GS3YEVSS12N6
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,203,750
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 46% complete
- Place of performance
- Berkeley, CA 94720, USA
Award details come from USAspending.gov.
Description
- Abstract
- The nuclear envelope (NE), a double-membrane structure surrounding the cell nucleus, and the nuclear pore complex (NPC), the largest protein assembly residing in the NE, together govern paramount cellular processes of the eukaryotic life, spanning chromatin organization, gene expression regulation, nucleocytoplasmic transport, and signal transduction. Our laboratory is committed to studying diverse and novel functions of the NE and NPC using plants as our model organisms. Our emphasis on plants stems from their unique combination of both conserved and distinct NE and NPC-associated mechanisms evolved in response to complex environmental challenges. In this proposal, we aim to leverage an integrated proteomic, molecular, genetic, and bioinformatic approach, to achieve a mechanistic understanding of how PNET1, a newly identified and evolutionarily conserved NPC membrane component, impacts mitotic progression in undifferentiated cells. Concurrently, we seek to elucidate the central role played by the NPC basket protein, GBPL3, in the precise regulation of stress-induced transcriptional reprogramming through the gene gating mechanism. This research endeavor is expected to significantly advance our understanding of fundamental biological principles underlying cell division and the regulation of gene expression occurring at the level of the NPC. Additionally, IT may offer potential avenues for therapeutic interventions targeting aberrant mitotic processes in critical human diseases (e.g., cancers) and provide insights into the precise manipulation of gene expression, both in native and engineered biological systems.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $401,250 | |
| Amendment | $401,250 | |
| Original award | $401,250 |
Quick answers
Who received award R35GM154623?
R35GM154623 was awarded to The Regents Of The University Of California by National Institute of General Medical Sciences (National Institutes of Health) on August 1, 2024.
How much is award R35GM154623 worth?
$1,203,750 has been obligated on R35GM154623.
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