Functional characterization of lysosome membrane and its protein quality control system
Active Project Grant Awarded Last action
- Award ID
- R35GM153356
- Recipient
-
Regents Of The University Of Michigan UEI GNJ7BBP73WE9
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,539,288
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 43% complete
- Place of performance
- Ann Arbor, MI 48108, USA
Award details come from USAspending.gov.
Description
- Abstract
- The lysosome is an important organelle responsible for digesting and recycling materials, nutrient sensing, and controlling cell proliferation. IT is also linked to neurodegenerative diseases, including alzheimer's, huntington's, and parkinson's diseases. Despite its importance, the regulation of lysosomal membrane protein composition and the function of its transporters and ION channels are not well understood. My lab has made significant progress in studying the turnover mechanisms of lysosomal membrane proteins by identifying a conserved ubiquitin- and escrt-dependent pathway for protein degradation. However, several key questions remain, including the identification of substrates of lysosomal E3 ligases in humans (future direction 1), the assembly of the escrt machinery to the lysosome membrane for internalizing ubiquitinated cargoes (future direction 2), and identifying other proteins involved in the quality control process. Additionally, there is a lack of understanding of the substrates, direction of transport, and energy dependence of many lysosomal transporters and ION channels (future direction 3). My lab has developed a reconstitution platform to study lysosomal membrane transport proteins, which will be combined with conventional methods such as metabolomics of isolated lysosomes to better understand these processes.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $384,822 | |
| Amendment | $384,822 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $384,822 | |
| Original award | $384,822 |
Quick answers
Who received award R35GM153356?
R35GM153356 was awarded to Regents Of The University Of Michigan by National Institute of General Medical Sciences (National Institutes of Health) on September 1, 2024.
How much is award R35GM153356 worth?
$1,539,288 has been obligated on R35GM153356.
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