Project Grant R35GM153276
Award Date
8/15/24
Completion Date
6/30/29
Dollars Obligated
$800K
Funding Federal Agency
Assistant Secretary for Financial Resources
Awarding Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
Similar Awards
The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $1,793,116 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Wisconsin-Madison. The grant supports the development of innovative synthetic methods to rapidly access stereochemically complex and functionally dense nitrogen-containing small molecules, including azetidines, pyrrolidines, piperidines, and amine-bearing carbocycles. The research aims to unlock new...
This $368,110 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to study the structures and properties of key enzymatic intermediates involved in oxygenase chemistry. The research aims to develop peptide-based synthetic models that can mimic the active sites and reactivity of non-heme iron and copper oxygenases, which are critical for metabolism, natural product...
This $146,816 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to develop biocatalytic strategies for the synthesis of N-N and C-N heterobiaryl atropisomers. The research aims to employ bioinformatic techniques to identify flavin-dependent aromatic hydroxylase (FDAH) enzymes that can catalyze direct, atroposelective oxidative coupling reactions to form these medicinally relevant...
This $444,262 federal project grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of innovative chemical reagents and methods for the synthesis of oligophosphate constructs. The research aims to enable the study of protein oligophosphorylation, a key post-translational modification, and the creation of covalently-linked oligophosphate-organic molecule conjugates. The award will fund...
This $1,114,113 project grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development and application of reactions to enable molecular rigidification at the University of North Carolina at Chapel Hill. The goal is to develop reactions that increase the rigidity of small and medium-sized molecules, which can improve their likelihood of success as drug candidates. The research program will...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), awarded a $357,056 Project Grant to Wayne State University to adapt heterogeneous materials and macromolecules for use in high-throughput organic synthesis approaches. The key objectives of this 5-year grant, beginning on January 1, 2025, are to: 1) develop colloidal suspensions of insoluble inorganic reagents to enable their processing in automated liquid...
This $350,000 Project Grant award from the National Institutes of Health (NIH) under the Biomedical Research and Research Training program (CFDA 93.859) supports time-resolved and multi-temperature structural biology research to understand dynamic enzyme catalysis at Baylor University. The research aims to combine enzyme structure and kinetics into a single experiment using time-resolved structural biology techniques to uncover reaction intermediates and structural fluctuations of enzymes...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of engineered enzymes that can be activated to perform targeted modifications of cellular proteins. The $1,602,000 award to the Dana-Farber Cancer Institute, Inc. (DFCI) will fund research to design and apply novel autoinhibited enzymes that can toggle between inactive and active conformations in response...
This Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will fund the development of new catalytic stereoselective methods and synthesis logics to enable reliable access to complex bioactive natural and unnatural compounds. The $1,170,000 award to the University of Texas at Dallas (UTD) aims to solve critical synthesis challenges for terpenes and alkaloids that have potential for treating...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $495,117 to the University of Wisconsin System to conduct research focused on accessing the hidden biosynthetic capabilities of fungi. The key objectives are to: (I) elucidate the products of isocyanide synthase (ICS) biosynthetic gene clusters (BGCs) that contain unusual enzymatic features, unique chemistries, and/or target...