Mechanisms of vesicle trafficking and kinesin regulation
Active Project Grant Awarded Last action
- Award ID
- R35GM153259
- Recipient
-
Rensselaer Polytechnic Institute UEI U5WBFKEBLMX3
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,992,808
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 46% complete
- Place of performance
- Troy, NY, USA
Award details come from USAspending.gov.
Description
- Abstract
- Nearly every aspect of cellular function-from development to metabolism and signaling-requires that membrane proteins be targeted to the correct location in the cell. This process requires high specificity as different cargoes are destined for different destinations. Although the basic steps of this process are known (i.e., cargoes are sorted into vesicles, the proper kinesins are recruited, and kinesins then transport vesicles to the proper destination), our current understanding of the mechanisms by which kinesins are recruited to vesicles and how their action is regulated on vesicles in live cells is extremely limited. Previously, the field lacked many of the tools needed to better characterize and understand these mechanisms, but our group has developed several cutting-edge tools that allow US for the first time to answer several fundamentally important questions. In this project, we will apply our experience with these tools in combination with primary hippocampal neuron culture and live cell imaging to achieve four key goals: 1) determine the mechanisms of on-vesicle regulation for kinesin- mediated transport, using kinesin-3 family member KIF13A as an initial model, 2) identify molecular links between cargo sorting and kinesin recruitment, 3) determine the mechanisms that underlie the sorting of polarized cargoes at the trans-golgi network, and 4) develop additional molecular tools in pursuit of these goals that also have applicability to the broader trafficking community.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $399,830 | |
| Amendment | $398,909 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $398,023 | |
| Amendment | $398,023 | |
| Original award | $398,023 |
Quick answers
Who received award R35GM153259?
R35GM153259 was awarded to Rensselaer Polytechnic Institute by National Institute of General Medical Sciences (National Institutes of Health) on July 1, 2024.
How much is award R35GM153259 worth?
$1,992,808 has been obligated on R35GM153259.
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