Project Grant R34CA297502
- Federal Grant Award Summary Thomas Jefferson University (Sidney Kimmel Medical College) received a $484,405 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2030. This five-year award supports fundamental cancer biology research investigating NSD2 (Nuclear Set Domain Family Member 2) mutations and their role in driving acute lymphoblastic leukemia (ALL) transformation. The research...
- Federal Grant Award Summary Thomas Jefferson University (operating as Sidney Kimmel Medical College) received a $646,208 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period May 1, 2026 through April 30, 2031. The award supports research investigating spatial heterogeneity of Human Epidermal Growth Factor Receptor 2 (HER2) expression in luminal estrogen receptor-positive (ER+) breast cancer. The project aims to...
- Federal Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $401,115 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period August 1, 2025, through July 31, 2027. The award funds research to develop and validate contrast-enhanced ultrasound (CEUS) as a diagnostic tool for evaluating hepatocellular carcinoma (HCC) treatment response following transarterial...
- Federal Grant Award Summary The University of Virginia received a $415,257 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), effective July 1, 2026 through June 30, 2028. The grant funds development of a comprehensive intervention to address financial toxicity (FT)—a multidimensional construct encompassing material burden, psychosocial distress, and coping behaviors driven by financial strain—among cancer survivors and...
- Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $1.66 million Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), awarded March 6, 2026, with a completion date of February 28, 2031. This five-year research initiative addresses neuroendocrine prostate cancer (NEPC), an aggressive variant that emerges in approximately 25% of prostate cancer patients following androgen suppression...
- Federal Grant Award Summary The National Cancer Institute awarded a $122,610 Project Grant to the University of Pennsylvania on August 11, 2025, under the Cancer Treatment Research program (CFDA 93.395). The award, with a completion date of July 31, 2030, supports the development of a system to advance National Cancer Institute (NCI)-sponsored clinical trials for patients with rare gastrointestinal malignancies and rare disease populations. The project leverages the principal investigator's...
- Federal Project Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $1.1 million Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), effective June 1, 2026, through May 31, 2030. The project, titled "Chemoradiation Imparts KRAS-Mediated Resistance to Immunotherapy in Non-Small Cell Lung Cancer," supports basic and applied biomedical research addressing Service...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under its Cancer Research Manpower program (CFDA 93.398), awarded $460,857 to the University of Pennsylvania on August 1, 2025, for a five-year project (completion date: July 31, 2030) titled "Tobacco Treatment Skills Training and Implementation Strategies to Reduce Preventable US Cancer Outcome Variations." The project addresses a critical gap in tobacco cessation treatment delivery by developing and...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $668,691 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) on March 11, 2026, with a completion date of February 28, 2031. The award supports a hierarchical 2x2 factorial randomized controlled trial designed to evaluate two complementary interventions addressing the treatment burden experienced by older women (age 65+) receiving...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $186,000 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 23, 2025, with a completion date of May 31, 2027. The award supports pilot and feasibility studies for NN-01-195, a novel tumor-targeted Aurora-A kinase (AURKA) inhibitor developed through a drug conjugate approach. The research involves preclinical evaluation of this chimeric compound, which fuses an...
Thomas Jefferson University (Sidney Kimmel Medical College) received a $312,363 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) effective July 1, 2026 through June 30, 2029. The award supports development and evaluation of a remotely-delivered Tai Chi intervention, designated TaiChi4NerveEase, targeting chemotherapy-induced peripheral neuropathy (CIPN) in older gastrointestinal cancer patients aged 65 and above. The study follows the ORBIT (Obesity Research and Behavioral Interventions Testing) framework across two phases: Phase I involves 12 patients participating in focus groups and one-week usability testing to refine the intervention design, while Phase II conducts a proof-of-concept randomized controlled trial with 60 patients assigned to either the intervention or active control group for 12 weeks with post-intervention and three-month follow-up assessments. The project addresses a significant clinical need, as approximately 60% of CIPN cases in older cancer patients result in impaired physical function, elevated fall risks, and reduced quality of life with limited effectiveness from conventional pharmacological treatments. Feasibility benchmarks include achieving 70% consent rate, 80% online session attendance, 75% assessment completion, and 90% treatment fidelity. This research contributes to the Cancer Treatment Research program's broader objective of developing improved cancer treatment modalities and supportive care methods to enhance patient outcomes and quality of life.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $312.4k | 6/30/26 |