Planning grant for a randomized controlled trial of scoliosis-specific physiotherapy for adolescent idiopathic scoliosis

Ended Project Grant Awarded Last action

Award ID
R34AR083625
Recipient
Awarding agency
Obligated
$793,626

Award facts

Completion date
Place of performance
Michigan, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Adolescent idiopathic scoliosis (AIS) is a spinal deformity of unknown etiology, resulting in rotation and abnormal curvature. Associated physical signs include uneven shoulders and waist, rib and flank protrusions, as well as HIP misalignment. Scoliosis also affects psychological wellbeing, and can cause cardio-respiratory issues, pain, discomfort and disability in older ages. AIS is a relatively common pediatric musculoskeletal condition, affecting 0.5%-5.2% of adolescents. Females are disproportionally affected, with a female-to-male ratio of 10:1 in curves larger than 50°. Scoliosis progression can accelerate rapidly over a short period of time, particularly during growth spurts. The most common treatment for AIS is observation ("watchful waiting") for children with curves between 10°-25°, bracing for curves 25°-45°, and surgery typically recommended for growing children with curves >45°. Every year in the USA there are ~29,000 scoliosis surgeries, each costing ~$92,000 USD. Surgery is irreversible and comes with risk of blood loss, infection, neurological compromise, or pseudarthrosis that requires reoperation. Recent studies demonstrate great promise for specialized physiotherapeutic scoliosis specific exercise (psse), such as "schroth" therapy, for decelerating or preventing progression, and improving outcomes. There is a crucial need for expanding the related evidence base, through a rigorous and adequately powered multi-center randomized controlled trial (RCT). The proposed project will lead to development of such a trial, with preparation and submission of a corresponding U01 application to fund the RCT conduct. Our overarching hypothesis is that scoliosis-specific physical therapy in skeletally immature children with mild and moderate scoliosis (curves

Transactions

Action Obligated Date
Amendment $0
Amendment $87,372
Amendment $87,372
Amendment $309,441
Original award $309,441

Subawards

Subrecipient Amount Awarded
Curvy Spine Inc. As MPI for this planning grant, Dr. Schreiber will collaborate with Dr. Somers to oversee all aspects of the planning period. As this will include regular… $36,078

Quick answers

Who received award R34AR083625?

R34AR083625 was awarded to Regents Of The University Of Michigan by National Insititue of Arthritis and Musculoskeletal and Skin Diseases (National Institutes of Health) on February 1, 2024.

How much is award R34AR083625 worth?

$793,626 has been obligated on R34AR083625.

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