This federal Project Grant award, valued at $322,408 and provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research under CFDA program 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research. The research aims to define how mechanically-evoked calcium signaling across 3D osteocyte networks in bone modulates the spatiotemporal remodeling of osteoblasts and osteoclasts in normal and injured conditions. The project will utilize a novel...
This federal Project Grant award in the amount of $375,100.00, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the cellular mechanisms of age-associated cortical bone remodeling. The two-year deliverables of the proposed study are: 1) identification of myeloid progenitors that aid in maintenance of cortical bone with age, and 2)...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $626,879 to the University of Southern California to conduct research on cellular and molecular mechanisms driving large-scale bone regeneration. The research aims to unravel the intricate cellular and molecular events necessary for extensive bone repair, focusing on understanding...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $783,176 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Mayo Clinic to develop and validate a quantitative spine imaging methodology using photon-counting detector computed tomography (PCD-CT) for comprehensive assessment of bone quality in patients undergoing pharmacologic therapy for osteoporosis. The project aims to enable accurate characterization of cortical...
This federal Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is focused on building a comprehensive data repository to collect and share bone phenotyping data from rodent animal models. The total award amount is $522,334.00, with a project period from September 2024 through July 2028. The key products and services to be delivered include:...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $599,693 to support research into the negative regulation of osteoclastogenesis - the process of generating bone-resorbing cells. The overarching goals are to elucidate the molecular pathways and mechanisms that regulate myeloid cell function and osteoclastogenesis under...
This $456,808 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of innovative mass spectrometry imaging (MSI) technologies to spatially visualize proteins and glycans in musculoskeletal tissues. The primary awardee, the Buck Institute for Research on Aging, is collaborating with researchers at the University of...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $220,224 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The Regents of the University of Colorado, effective July 4, 2024 through August 31, 2027. The grant supports the development of granular hydrogels for the controlled delivery of immunomodulatory and angiogenic extracellular vesicles to enhance bone tissue regeneration. As a prominent public...
This federal Project Grant award, ID R01AR084693, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The $1,938,605 award to the Van Andel Research Institute (VAI) in Grand Rapids, Michigan will fund research to determine the mechanisms by which the X-linked chromatin modifying enzyme KDM5C regulates bone mass in females. The project aims to investigate how loss...
This Project Grant award, totaling $1,268,214.00, was made by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award will fund research to investigate the role of skeletal muscle alpha-actin (SKA) in the nucleus and its relationship to the development of intranuclear rod myopathy, a severe congenital muscle disorder. Key research objectives include identifying SKA's nuclear...