Project Grant R34AI184342
- This Project Grant award in the amount of $521,839.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports research at the University of California, San Diego to investigate the molecular mechanisms underlying the activation of microglia, which contribute to oxidative stress and tissue damage in multiple sclerosis (MS)....
- This $198,928 Project Grant was awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant will support research at the University of California, San Francisco to elucidate the cellular mechanisms underlying central nervous system injury and progression in multiple sclerosis. Key objectives include determining the role of astrocyte response,...
- This $979,138 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of a multivariate machine learning analysis of blood-based RNA expression profiles to distinguish relapsing-remitting and progressive forms of multiple sclerosis. The award, with a performance period from August 1, 2025 to July 31, 2027, was granted to Decode Health, Inc. to advance...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $104,433 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Washington University in St. Louis to conduct research on examining microglia reactivation in multiple sclerosis (MS). The project aims to define the gene signature of disease-associated microglia (DAM) and understand how the function of these cells is affected by repeated activation, as...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $300,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Texas Southwestern Medical Center (UT Southwestern) to develop immune checkpoint-engineered oligodendrocytes as a potential treatment for multiple sclerosis. The grant supports two key aims: 1) formulating checkpoint-engineered oligodendrocytes using stem cells and induced pluripotent stem cells, and 2)...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $418,493 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Boise State University in Boise, ID. The grant will fund research to investigate the therapeutic mechanisms of farnesol in modulating gut dysbiosis and neuroinflammation in multiple sclerosis (MS). The project aims to determine if farnesol prevents the onset and progression of experimental autoimmune encephalomyelitis...
- This $4,164,187 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop antigen-directed therapies for autoantibody associated neuroinflammatory diseases. The project aims to facilitate the discovery of autoantibodies directed to cell surface antigens, characterize their specificity, and generate recombinant human...
- This $2,291,595 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports a longitudinal study to determine whether Epstein-Barr virus (EBV)-induced molecular mimicry is a likely cause of multiple sclerosis (MS) in African Americans. The award will fund a study using blood samples collected from over 10 million active duty U.S. military personnel to investigate the relationship...
- This Project Grant award of $305,000.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of stem-like T cells in multiple sclerosis (MS) disease progression. The key objectives are to: Rigorously test the hypothesis that a continuing stemness and differentiation of CD4+ T stem cells results in functional and transcriptomic diversification under evolving...
- This three-year $872,936 project grant from the National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, will fund research into the regulation of the microglial neuroimmune response by long non-coding RNAs. The grantee, Creighton University, will investigate how specific long intergenic non-coding RNAs (lincRNAs) mediate a proinflammatory state in microglia and determine if differential lincRNA expression underlies viral-induced mouse models of...
This $263,892 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to evaluate the use of oral N-acetylglucosamine (GlcNAc) as an anti-neuroinflammatory add-on therapy for patients with multiple sclerosis (MS). The project, titled "ORAL N-ACETYLGLUCOSAMINE AS ANTI-NEUROINFLAMMATORY ADD-ON THERAPY FOR MULTIPLE SCLEROSIS (NANA-MS)", will be conducted by the University of California, Irvine from August 1, 2025 to July 31, 2026. The research seeks to assess whether oral GlcNAc can suppress inflammatory demyelination, promote myelin repair, and reduce neurodegeneration in MS patients by crossing the blood-brain barrier and modulating immune responses and glycan pathways. This builds upon previous open-label trials that found oral GlcNAc therapy was safe and had beneficial impacts on inflammatory cytokines and glycan profiles in MS patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $263.9k | 7/29/25 |