Project Grant R33CA287046

Award Date 9/1/24
Completion Date 8/31/27
Dollars Obligated $407K
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
Boston, MA 02215, USA
Similar Awards
The National Cancer Institute (NCI) awarded a $632,300 Project Grant under the Cancer Biology Research program (CFDA 93.396) to Carnegie Mellon University. The grant will fund the development of an integrated ultrahigh-throughput 3D volumetric super-resolution imaging system. This system will combine a multiscale fluorescence mesoscope with magnify expansion microscopy to enable rapid, large-area 3D imaging with exceptional subcellular detail. The goal is to study interactions between cancer and...
The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Massachusetts Institute of Technology (MIT) for $351,010. The grant, with a period of performance from January 1, 2025 to November 30, 2029, focuses on the rational design, synthesis, and characterization of cationic carbone-boracycles as far-red and near-infrared photoactive agents for applications in bioimaging and cancer therapy....
This Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to Beth Israel Deaconess Medical Center, Inc. (BIDMC) provides $749,474 to conduct research aimed at understanding the underlying mechanisms of failed inflammation resolution in chemical-induced cancers. The research will focus on profiling lipid autacoid mediators, including eicosanoids and specialized pro-resolving mediators (SPMs), as well as cytokines, to evaluate their role in regulating...
The National Cancer Institute (NCI) awarded a $417,586 Project Grant (CFDA 93.396 - Cancer Biology Research) to The Broad Institute, Inc. to develop a "Platform for Multi-Modal Single Nucleus Spatial Genomics for Molecular Tumor Analysis." This 3-year project, commencing on August 1, 2024, aims to extend the institute's "Slide-Tags" single-cell spatial genomics technology to enable comprehensive profiling of human tumor samples. The project will integrate molecular, cellular,...
The National Cancer Institute (NCI), under CFDA 93.396 - Cancer Biology Research, awarded a $449,726 project grant to the University of Illinois to develop tools that enable the rapid analysis of changes in protein interactions within living cells. The project aims to significantly improve the sensitivity and temporal resolution of existing proximity labeling approaches used to map dynamic protein interactomes. Key innovations include engineering biotin ligases that can label proteins with...
This Project Grant award of $603,803 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) will support research by the University of Massachusetts Boston to investigate the biomechanical and biomolecular properties of large extracellular vesicles (L-EVs) and their potential as cancer biomarkers. The collaborative project aims to advance microfluidic technology to measure single L-EV characteristics and explore the clinical utility of multiplex L-EV profiling from plasma...
This federal Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) provides $427,095 to Northeastern University to develop a novel microfluidic droplet-based platform (MDP) technology. The MDP will generate and analyze a 3D biomimetic multicellular immunogenic tumor model to: Establish multiple levels of hypoxia within the same tumor-chip for parallel processing. Investigate spatiotemporal interaction between the...
This $222,027 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research (CFDA 93.396) program supports the development of a novel computational imaging algorithm to characterize the mechanobiology of three-dimensional tumor microenvironments (TMEs). The University of Pittsburgh, the grant's recipient, aims to combine high-resolution digital pathology imaging and highly multiplexed immunofluorescence microscopy with physical optics-based principles to...
This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), provides $399,491 to Northridge Tri-Modality Imaging Inc. to upgrade their gantry-based imaging system to incorporate bioluminescence tomography (BLT) capabilities. The upgraded system will enable 3D whole-body fluorescent, bioluminescent, and anatomical X-ray imaging of small animal cancer models, providing a comprehensive multimodal imaging...
This federal Project Grant award of $147,486, awarded on December 1, 2025 by the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program), supports research by Baylor College of Medicine to develop a novel "RECON" immune tolerization strategy. The goal is to investigate the trade-offs between oncogene pathogenicity and immunogenicity, which could enable dissection of the genetic and phenotypic alterations governing immune evasion independently of tumorigenesis during...

This federal Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) supports the development of a new bio-orthogonal mid-infrared photothermal imaging approach to quantitatively measure various molecular events in cancer cells at the subcellular level. The $407,113 award to Trustees of Boston University will be used to: 1) build a library of nitrile-based probes to sense important molecular events inside cancer cells; 2) develop nitrile-tagged small molecules to measure nutrient metabolism in cancer cells; and 3) create a microsecond-scale mid-infrared heating spectroscopy system to enable multiplexed bio-orthogonal imaging. The goal is to provide researchers with a novel tool to quantify molecular processes in cancer cells and potentially enable new precision diagnostics and treatment approaches. The award period runs from Sep 1, 2024 to Aug 31, 2027.

Generated 7/1/25, 5:19 AM