Project Grant R25NS137380

Award Date 9/1/24
Completion Date 8/31/29
Dollars Obligated $180K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Cold Spring Harbor, NY 11724, USA
Similar Awards
This federal Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), supports a three-year Drosophila neurobiology course at Cold Spring Harbor Laboratory (CSHL) from 2024-2027. The $182,400 award will fund an intensive, hands-on course that provides advanced training in genetic, molecular, cellular, behavioral, and computational approaches for studying the neural basis of fly behavior. The course is designed to introduce students to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The $481,250 award, spanning September 2024 to September 2026, will enable the researchers to integrate subcellular...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $235,887 to Stony Brook University to develop a chemical strategy for imaging neural synapses and circuit connectivity in post-mortem specimens. The proposed approach combines immunochemistry and lipophilic tracers to enable light microscopy-based visualization of synapse formation...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $404,340 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Georgia Research Foundation, Inc. The project aims to develop a novel method using split fluorescent protein tags to map the localization of neurotransmitter receptors within neural circuits in the Drosophila model organism. This work will provide crucial new insights into the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $272,000.00 to support a Clinical Trials Methodology Course in Neurological Disorders (CTMC). The goal of this training program is to supply the healthcare system with effective clinical researchers and biostatisticians capable of implementing well-designed clinical...
This $1,417,500 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) funds the development of "Electrified Cryo-EM", a novel tool that can kinetically trap biological systems in their metastable, non-equilibrium states. The research aims to unravel the structural changes in neurons during an action potential across multiple length scales, from voltage-gated channel proteins to the synaptic junction. Specifically,...
The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services, awarded a $4,528,840 Project Grant to The Salk Institute For Biological Studies under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The three-year award beginning August 19, 2022 will fund research to functionally dissect cerebellar output circuits that orchestrate limb motor control. Specifically, the grantee will...
This federal Project Grant award, with the ID R35NS132231, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $885,128 grant supports research aimed at gaining a molecular-level understanding of the design principles governing somatosensation and nociception by membrane sensory receptor channels, as well as broader contextualization. The research, led...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $433,159 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Maryland, Baltimore. The grant, effective August 1, 2024 through June 30, 2029, will fund research to define the precise mechanisms through which calcium-activated chloride channels in brain pericytes contribute to the control of capillary blood flow and how neuronal...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $244,154 to Albert Einstein College of Medicine to investigate the regulation of presynaptic gene transcripts during synaptogenesis in the nematode C. elegans. The research aims to characterize the dynamics of the SYD-2/LIPRIN-alpha mRNA and identify novel candidates for mRNA...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $179,836 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Cold Spring Harbor Laboratory for the "ION CHANNELS IN SYNAPTIC AND NEURAL CIRCUIT PHYSIOLOGY COURSE" from September 1, 2024 to August 31, 2029.

The primary goal of this course is to demonstrate, through lectures and laboratory work, the different properties of ion channels that enable neurons to perform unique physiological functions in a variety of neural systems. The laboratory component provides trainees hands-on experience using patch-clamp electrophysiology to examine single channel activity, ion channel biophysics, action potential firing, synaptic integration, plasticity, and circuit dynamics in cultured cells, acute brain slices, and in vivo models. The course also provides practical experience in cellular and circuit manipulation techniques such as pharmacological, electrophysiological and optogenetic approaches both in vitro and in vivo.

Generated 7/1/25, 4:08 AM