The National Institute of General Medical Sciences (NIGMS) awarded a $21,919,037 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to The New York Structural Biology Center, Inc. (NYSBC) to operate the National Center for Cryo-EM Access and Training (NCCAT). The NCCAT enables researchers to rapidly solve high-resolution macromolecular structures using state-of-the-art cryo-electron microscopy (cryo-EM) instrumentation and expert technical support. The...
The National Institute of General Medical Sciences (NIGMS) has awarded a $1,999,999 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to establish a Midwest Regional Cryo-Electron Microscopy (Cryo-EM) Facility. The grant will fund the acquisition and installation of a 200 kV Glacios Cryo-Transmission Electron Microscope equipped with a Falcon 4i direct electron detector and...
This two-year, $219,836 National Science Foundation Integrative Activities Project Grant supports training in cryogenic electron microscopy (cryo-EM) for researchers at the University of Nebraska-Lincoln. The grant enables a research team to acquire hands-on cryo-EM training from experts at the Pacific Northwest Center for Cryo-EM, a user facility operated by Oregon Health & Science University and Pacific Northwest National Laboratory. Upon completing the training, the researchers will...
The National Institute of General Medical Sciences (NIGMS) has awarded a $344,400 project grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to develop new techniques to improve cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) imaging. Specifically, the project aims to: 1) Develop a sample preparation strategy to reduce electron-induced radiolysis of frozen-hydrated biological specimens, thereby...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $3,999,999.00 to the Icahn School of Medicine at Mount Sinai (ISMMS) to purchase a GLACIOS 2 cryo-electron microscope (cryo-EM). This state-of-the-art cryo-EM instrument will enable researchers across ISMMS to conduct cutting-edge structural biology studies on a wide range of biological systems and disease mechanisms. The award will...
This $1,200,000 Project Grant awarded by the National Science Foundation (CFDA 47.074 - Biological Sciences) will support The Trustees of Columbia University in the City of New York in developing a time-resolved cryo-electron microscopy (cryo-EM) method to study the dynamics of biological molecules, including RNA polymerase, GLP1R, and the multi-drug efflux transporter AcrB. The research aims to broaden the application of this technique to expand understanding of molecular interactions in...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $390,000.00 in funding to Oregon Health & Science University (OHSU) over a 5-year period from September 1, 2024 to July 31, 2029. The objective of this award is to pioneer new technologies that revolutionize the study of transcription factor-coregulator interactions, which are pivotal in directing gene regulation, cellular...
This federal Project Grant award of $597,573.00 was issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports advanced structural and dynamic studies of large protein and protein-nucleic acid complexes and assemblies that play key roles in human health and disease. The research aims to provide atomic-level insights into the structure, dynamics, interactions, and function of chromatin...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to improve the quality of cryogenic electron microscopy (cryo-EM) specimens. The $349,999 award to Denovx, LLC will fund research to develop innovative surface modifications for cryo-EM specimen supports that enhance the adsorption and random orientation of biological analytes, such as proteins and protein complexes. The researchers will...
The Department of Health and Human Services' National Institute of General Medical Sciences awarded Oregon Health & Science University a $2,680,200 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) for the period September 1, 2022 through August 31, 2025. The grant will support research to elucidate signaling pathways of the P2X7 purinergic receptor and develop novel small molecule and aptamer ligand therapies. Specifically, the recipient will utilize...
The National Institute of General Medical Sciences (NIGMS) awarded a $21,072,791 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Oregon Health & Science University (OHSU) on August 10, 2024. The grant establishes the Pacific Northwest Center for Cryo-EM (PNCC), which aims to provide access and training in cutting-edge cryo-electron microscopy technology to the structural biology community.
As part of this grant, OHSU has partnered with Battelle Memorial Institute to support the PNCC's research and service delivery. Battelle Memorial Institute will provide specialized research services in areas such as microbiology, virology, cardiology, and cryo-electron microscopy to complement OHSU's capabilities. The grant will fund the development of new workflows, training programs, and outreach efforts to democratize access to cryo-EM technology and accelerate advancements in biomedical research over the 5-year award period.