This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on the discovery and development of novel schistosomicidal (anti-schistosome) agents. The $600,000 award, with a period of performance from June 2024 to May 2025, will support research to optimize novel inhibitors of the schistosome enzyme thioredoxin glutathione reductase (TGR) for oral bioavailability, while...
This $361,107 Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports two key research focus areas at Clemson University. First, the award will fund the development of new synthetic methodology to access rare nitrogen-rich heterocyclic compounds, which have shown potential anti-parasitic activity and may unlock additional biological applications. This work aims to expand the...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $1,373,790 to Oregon Health & Science University (OHSU) to optimize the structural features of the antimalarial drug candidate ELQ-596. The goal is to develop a next generation of ELQ compounds for once-monthly oral prophylaxis against malaria in humans. The project leverages the expertise of a collaborative team in medicinal...
This Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) provides $317,029 in funding to Chemia Biosciences, Inc., a small disadvantaged business, to develop advanced computational methods and software tools for discovering novel antimicrobial natural products. The project aims to leverage high-throughput mass spectrometry and genome mining techniques to identify new polysaccharides and aminoglycosides, a class of antibiotics, to address the growing...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the Department of Health and Human Services National Institutes of Health, is for the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286). The $249,000 grant awarded to Clemson University will fund the development of a novel split enzyme diagnostic platform for rapid, sensitive detection of biomarkers at the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $153,056 to The Washington University in St. Louis to conduct research on heme homeostasis in the malaria parasite Plasmodium falciparum. The research aims to identify parasite proteins involved in maintaining cytosolic heme concentrations and investigate the role of the heme detoxification protein PfHDP in heme...
This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development of a murine glioblastoma model to evaluate the use of oncolytic herpes simplex virus (HSV) therapy for grade IV brain tumors. The total funding amount is $794,967.00, with a project period from July 9, 2024 to June 30, 2026. The goal is to create an...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the development of novel, brain-penetrant drugs for Alzheimer's disease therapeutics. The $994,436 award to Transchromix LLC, located in Chapel Hill, NC, funds research to investigate the role of the histone methyltransferase G9A in Alzheimer's disease pathogenesis. The project aims to elucidate the non-canonical, translation regulatory function of G9A and evaluate the mechanism of action for...
This federal Project Grant award, valued at $226,738.00 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), is intended to support research aimed at enhancing the efficacy of the anthelmintic drug emodepside for treating filarial nematode infections. The key objectives of this two-year project are to: 1) characterize the pharmacology of the endogenous SLO-1/2 potassium channels in...
This $189,635 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop novel structure-based therapeutic approaches for treating Balamuthia mandrillaris infections, which cause a fatal condition called granulomatous amoebic encephalitis (GAE). The research team, led by investigators at Northeastern University, will focus on understanding the structure-activity...