Project Grant R21TR004265
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $220,050 to The Children's Hospital of Philadelphia Research Institute under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on August 1, 2025, for a five-year project concluding July 31, 2030. This Project Grant supports research to advance clinical trial readiness for SYNGAP1-related disorder (SYNGAP1-RD), a rare monogenic...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Leland Stanford Junior University a Project Grant totaling $228,420 effective August 1, 2025, through July 31, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This research initiative investigates genetic pathways and variants associated with neurodevelopmental outcomes in children exposed to anti-seizure...
- Summary: Neurophysiological Correlates of Cognition Over Multi-Day Timescales in Epilepsy The National Institute of Neurological Disorders and Stroke (NINDS) awarded Massachusetts General Hospital $234,630 on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct a five-year prospective research study examining the neurophysiological basis of cognitive impairment in temporal lobe epilepsy (TLE). The research...
- Federal Project Grant Award Summary New York University School of Medicine received a $247,994 Project Grant award effective March 1, 2026, through April 30, 2031, from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). Under this award, Dr. Andrew Michalak, Assistant Professor of Neurology at NYU Grossman School of Medicine, will conduct research to identify neural...
- Grant Summary Brigham & Women's Hospital Inc. received a $479,687 Project Grant award from the National Institute of Neurological Disorders and Stroke under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award, dated March 6, 2026, with a completion date of February 29, 2028, supports research aimed at identifying and restoring mechanisms driving epilepsy associated with Dentatorubral-Pallidoluysian Atrophy (DRPLA), a rare...
- This Project Grant, awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports research development at the University of California, Los Angeles to create predictive algorithms for pediatric postoperative complications. The $174,861 award, obligated on March 10, 2026, with completion targeted for February 28, 2030, funds the development and...
- Florida International University was awarded a $250,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an artificial intelligence-enabled real-time system for early epileptic seizure detection and prediction. The two-year project will design and develop advanced machine learning algorithms to identify neuromarkers in wearable electroencephalography data that can predict epileptic seizures. Researchers will...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $441,375 Project Grant (R21) awarded on April 13, 2026, by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating phenotype-genotype relationships in tuberous sclerosis (TS), a rare genetic disorder caused by mutations in the TSC1/2 genes that...
- Federal Cooperative Agreement Summary Cincinnati Children's Hospital Medical Center received a $3.94 million Cooperative Agreement from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded May 1, 2025, with completion scheduled for April 30, 2029. The award funds a multi-site Phase 3 randomized controlled clinical trial (RCT) examining "Epilepsy Journey,"...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $414,305 Project Grant to the University of Wisconsin–Madison, effective August 1, 2025, through July 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). This award supports research investigating the molecular and cellular mechanisms underlying epileptogenesis—the progressive process by which exposure to epileptogenic...
BRAIN MRI TO PRE-SYMPTOMATICALLY PREDICT SEIZURE ONSET FOR STURGE-WEBER SYNDROME - ABSTRACT STURGE-WEBER SYNDROME (SWS) IS A RARE NEUROLOGICAL DISEASE, AND ITS BIGGEST CONCERN IS NEUROCOGNITIVE IMPAIRMENTS BY SCHOOL AGE (6-10 YEARS). TO IMPROVE NEUROCOGNITIVE OUTCOMES, KENNDY KRIEGER INSTITUTE (DR. COMI, CO-PI OF THIS R21) AND BOSTON CHILDREN'S HOSPITAL (DR. PINTO, CO-PI OF THIS R21) HAVE BEEN THE LEADING OR KEY SITES IN VARIOUS CLINICAL TRIALS, TO TEST NEW TREATMENT (NCT02332655 (2014-19); NCT0304980 (2017-19); NCT04447846 (2019-21)), OR TO DEVELOP NEUROIMAGING BIOMARKERS THAT CAN SELECT AT-RISK PATIENTS (NCT01345305 (2010-2012); NCT01425944 (2010-2020); NCT04717427 (2021-2024)). HOWEVER, ALL THESE TRIALS FOCUS ON THE POST-SYMPTOMATIC PHASE - AFTER SEIZURE SYMPTOMS HAVE OCCURRED. OUR RECENT EVIDENCE SUGGESTED THAT PRE-SYMPTOMATIC TREATMENT - TREATING PATIENTS BEFORE SEIZURE SYMPTOMS OCCUR, IDEALLY BEFORE 2 YEARS OF AGE - MAY DELAY OR AVOID SEIZURE SYMPTOMS. THIS IS IMPORTANT, BECAUSE THOSE WITHOUT SEIZURE SYMPTOMS BY 2 YEARS OF AGE (10-25% OF SWS PATIENTS) OFTEN ENJOY GOOD NEUROCOGNITIVE OUTCOMES BY SCHOOL AGE. MOTIVATED BY THIS, MULTIDISCIPLINARY EXPERTS GATHERED AND REACHED A CONSENSUS IN 2018, 2019, AND 2021, CALLING FOR IMMEDIATE INVESTIGATIONS OF PRE-SYMPTOMATIC TREATMENTS. IN A TIMELY RESPONSE TO THIS CALL, KKI AND BCH, THE TWO LARGEST NATIONAL CENTERS THAT TREAT SWS PRE-SYMPTOMATICALLY, ARE PLANNING FOR A TRIAL TO COMPREHENSIVELY EVALUATE THE EFFECT OF ANTI-EPILEPSY DRUGS LEVETIRACETAM, IN TWO TREATMENT ARMS (LEVETIRACETAM WITH VERSUS WITHOUT LOW-DOSE ASPIRIN) FOR PRE-SYMPTOMATIC TREATMENT. THE BOTTLENECK ISSUE FOR THIS PLANNED TRIAL, THOUGH, IS THE LACK OF A BIOMARKER TO ACCURATELY AND PRE-SYMPTOMATICALLY IDENTIFY SWS PATIENTS WHO ARE AT RISK TO DEVELOP SEIZURE SYMPTOMS BY 2 YEARS OF AGE. THOSE AT-RISK PATIENTS SHOULD BE IDEAL CANDIDATES TO BE INCLUDED IN OUR PLANNED TRIAL. THIS R21 AIMS TO ADDRESS THIS BOTTLENECK BIOMARKER PROBLEM. WE PLAN TO RETROSPECTIVELY BUILD THE LARGEST MULTI-SITE PRESYMPTOMATIC DATABASE FROM CLINICAL DATA IN KKI AND BCH (AIM 1). WE WILL THOROUGHLY EVALUATE TWO CLINICAL AND BRAIN MRI BIOMARKERS TO IDENTIFY AT-RISK PATIENTS PRE-SYMPTOMATICALLY (AIM 2). THE CENTRAL HYPOTHESIS IS THAT SOPHISTICATED FEATURES THAT ARTIFICIAL INTELLIGENCE (AI) ALGORITHMS EXTRACT FROM CLINICAL AND BRAIN MRI COULD SERVE AS A BIOMARKER TO PRE-SYMPTOMATICALLY IDENTIFY SWS PATIENTS AT RISK OF DEVELOPING SEIZURE SYMPTOMS BY 2 YEARS OF AGE. THIS IS THE FIRST AI-POWERED, LARGE-DATASET-DRIVEN RIGOROUS STUDY FOR PRESYMPTOMATIC CLINICAL AND MRI BIOMARKERS FOR THIS RARE DISEASE. SUCH A BIOMARKER WILL BE IMMEDIATELY USED IN OUR PLANNED CLINICAL TRIALS TO EVALUATE LEVETIRACETAM WITH OR WITHOUT LOW-DOSE ASPIRIN FOR PRE-SYMPTOMATIC TREATMENT.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 12/12/25 | ||
| Not listed | $208.0k | 8/3/23 | ||
| Not listed | $271.1k | 8/9/22 | ||
| Not listed | $271.1k | 8/9/22 |