Project Grant R21OD042628
- The National Institutes of Health Office of the Director awarded $350,000 to Seattle Children's Hospital (doing business as Seattle Children's Research Institute) on September 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to purchase a digital ventilated cage system from Tecniplast for the Behavioral Phenotyping Core vivarium. The DVC system incorporates continuous, real-time monitoring of animal activity and environmental cage parameters including temperature, humidity,...
- The National Institute of General Medical Sciences awarded Seattle Children's Research Institute $2.096 million on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an AI-driven platform for generating conditionally stable nanobodies for intracellular detection and protein manipulation applications. The project spans four years through April 30, 2030, and will deliver three core outputs. First, an expanded AI-based nanobody stability prediction...
- The National Heart, Lung, and Blood Institute awarded Seattle Children's Hospital, doing business as Seattle Children's Research Institute, $1,839,440 on August 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate how heavy chain hyaluronan and TSG-6 modulate lung inflammation during respiratory syncytial virus (RSV) infection. The research examines the extracellular matrix's role in RSV pathogenesis, focusing on age-dependent inflammation in young children....
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Seattle Children's Hospital, doing business as Seattle Children's Research Institute, $724,950 on May 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to understand the mechanism of H3K9me3 heterochromatin-based silencing and selectively disrupt heterochromatin to improve the reprogramming of human fibroblasts into induced hepatocytes...
- The U.S. Department of Labor's Employment and Training Administration awarded a $350,000 Project Grant under the Community Project Funding/Congressionally Directed Spending program (CFDA 17.289) to Seattle Children's Hospital, doing business as Seattle Children's Research Institute. The award, effective May 1, 2024 through April 30, 2027, will fund the organization's diverse pediatric research initiatives, including work in areas such as infectious diseases, cancer, neuroscience, and rare...
- The National Institute of Allergy and Infectious Diseases awarded the University of Arizona $155,479 on June 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to generate transgenic mouse models that overcome immunological barriers to transplantation. The recipient will develop Cre-inducible transgenic mice expressing three distinct immune-evasion modules: genes that suppress complement deposition and membrane attack complex formation; single-chain peptide-B2M-MHC...
- The National Institute of Child Health and Human Development awarded The Morgridge Institute For Research, Inc., $131,832 on August 21, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research on appendage regeneration signaling and transcriptional programs. The award funds investigation into how signaling dynamics, transcriptional output, and physiological cues control regenerative growth in zebrafish dermal appendages, using live imaging,...
- The National Institute of Allergy and Infectious Diseases awarded Seattle Children's Hospital (doing business as Seattle Children's Research Institute) $859,765 on July 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of ferroptosis in regulating host control of Mycobacterium tuberculosis infection. The research examines how ferroptosis—a form of programmed cell death mediated by iron and lipid peroxidation—affects macrophage response to...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded $845,935 to the Research Institute At Nationwide Children's Hospital on July 21, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to establish a single-cell and spatial atlas of trisomy 21 hearts using both Down syndrome mouse models and patient-specific induced pluripotent stem cells. The award funds research aimed at elucidating cellular and tissue mechanisms of septal...
- The National Institute of General Medical Sciences awarded the University of Washington $380,371 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods that infer cellular history from single-cell sequencing data, enabling analysis of disease progression in tissues that cannot be sampled longitudinally, such as the brain in Alzheimer's disease or the heart in cardiomyopathy. The research deploys three integrated approaches:...
The Department of Health and Human Services National Institutes of Health Office of the Director awarded Seattle Children's Research Institute (doing business as Seattle Children's Hospital) $516,175 under the Research Infrastructure Programs (CFDA 93.351) on August 1, 2026, to develop transgenic technology in Acomys (spiny mice), a non-traditional mammalian model with naturally evolved adult non-fibrotic regenerative capacity. The recipient will establish whole-animal transgenesis pipelines in Acomys through two specific aims addressing in vitro and in vivo strategies for genome engineering. Current transgenic protocols developed in laboratory mice do not translate directly to Acomys due to unique reproductive physiology and embryo culture barriers. Overcoming these limitations will enable gene-level studies of regeneration, immunity, metabolism, and neuroscience, and accelerate validation of anti-fibrotic therapeutic targets. Fibrotic diseases and chronic inflammation affect multiple organ systems worldwide with limited effective treatments; understanding Acomys' naturally evolved resistance to fibrosis offers mechanistic insights unavailable in traditional pathological systems. Performance occurs in Seattle, Washington. The award runs through July 31, 2028. This is a Project Grant, an assistance type providing support for a discrete, specified research or development objective.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $516.2k | 7/28/26 |