Project Grant R21NS153438
- The National Institute of Neurological Disorders and Stroke awarded $471,861 to the University of Connecticut Health Center on March 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop transposon-mediated genetic manipulation techniques for studying oligodendrocyte precursor cells (OPCs) and their role in synapse formation. The research will develop improved techniques and test whether OPCs dynamically modulate...
- The National Institute of Neurological Disorders and Stroke, an operating division of the National Institutes of Health under the Department of Health and Human Services, awarded $660,625 to the University of Connecticut Health Center on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the cellular and molecular mechanisms of cerebellar hemisphere development. The research will examine how different...
- The National Institute of Neurological Disorders and Stroke awarded the University of Connecticut Health Center $1.815 million on August 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on the regulation of beta-glucocerebrosidase in Parkinson's disease and related dementias. The research examines how the protein GCIP1 regulates beta-glucocerebrosidase (GCase) processing, trafficking, and maturation in...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Yale University $667,613 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining ferroptosis—iron-induced programmed cell death—in erythrocytes within intracerebral hemorrhage hematomas. The project investigates how heme induces...
- The National Institute of Neurological Disorders and Stroke awarded Yale University $583,646 on March 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cilia disassembly and dysfunction in malformations of cortical development. Malformations of cortical development are neurological disorders characterized by altered organization and function of cortical neurons, often resulting in intractable epileptic...
- The National Institute of Child Health and Human Development awarded the University of Connecticut Health Center $457,875 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and deploy an inducible gene dosage correction system in Down syndrome organoid and rodent models carrying human chromosome 21. The research uses an XIST-based transgene system to reversibly silence one copy of chromosome 21 across multiple cell types,...
- The National Institute of Neurological Disorders and Stroke awarded Yale University $513,602 on June 19, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to define the role of non-clustered protocadherins in forebrain circuit assembly and complex behavioral execution. The research explores how non-clustered protocadherins, including protocadherin-17, establish reciprocal connectivity patterns between forebrain regions—the cerebral...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $167,500 on July 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to determine biochemical roles for DPF1, DPF3, and PHF10 subunits in mammalian BAF ATP-dependent chromatin remodeling complexes. The research addresses molecular functions of these proteins, which are associated with neurodevelopmental disorders...
- The National Institute of General Medical Sciences awarded the University of Connecticut Health Center $139,821 on August 1, 2026, to investigate how splicing factor homeostasis shapes transcriptomes in pluripotency and differentiation under the Biomedical Research and Research Training program (CFDA 93.859). The research uses in vivo reverse genetics and long-read RNA sequencing to characterize how poison exons in the splicing factors SRSF3 and TRA2B shape mouse embryonic development. A...
- The National Institute of Neurological Disorders and Stroke awarded Yale University $462,151 on May 19, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate genetic mosaicism and molecular mechanisms in human cerebral cavernous malformations. The project focuses on familial cerebral cavernous malformation, a cerebrovascular disease characterized by vascular lesions in the central nervous system that cause seizures and...
The National Institute of Neurological Disorders and Stroke awarded the University of Connecticut Health Center $462,950 on September 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular mechanisms underlying brain-specific vulnerability to ASPM loss in microcephaly. The research employs an ASPM knockout ferret model to define why mutations in the ubiquitously expressed ASPM gene cause severe brain-specific growth deficits while sparing other highly proliferative organs. The recipient will pursue two specific aims: Aim 1 quantifies proliferation and cell death across four ASPM-expressing tissues—cortex, lung, kidney, and intestine—in embryonic ferrets, and employs Seq-Scope spatial transcriptomics to map progenitor-specific stress responses in situ; Aim 2 identifies molecular mediators of this vulnerability through antibody-directed proximity labeling and related molecular techniques. The work is classified as a Project Grant (R21 mechanism), an exploratory research award. Performance occurs in Farmington, Connecticut. The period of performance runs from the award date through August 31, 2028. The University of Connecticut Health Center, a state-controlled academic medical center and comprehensive research institution, serves as the prime recipient.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $463.0k | 9/3/26 |