Project Grant R21NS150922
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on March 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to exploit RNA biogenesis, specifically alternative splicing programs, to accelerate maturation of human neurons in vitro and to develop models of age-related tauopathies. The research addresses a fundamental...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research dissecting the synaptic and molecular mechanisms of cell-type-specific memory computation in the hippocampal CA3 network. The award funds in vivo imaging, genetic perturbations, transcriptomics, and computational...
- The National Institute of Neurological Disorders and Stroke awarded $198,728 to The Trustees of Columbia University in the City of New York on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research quantifying relationships between behavior, neural network activity, and metabolic dysfunction in a genetic mouse model of developmental epileptic encephalopathy. The investigator will measure behavior and...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $589,156 on February 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project investigates s-palmitoylation as a regulatory mechanism for CAV2.1 and CAV2.2 calcium channels in presynaptic neurons. These channels mediate calcium influx that triggers neurotransmitter release at chemical synapses and...
- The National Institute of Neurological Disorders and Stroke awarded Sanford Burnham Prebys Medical Discovery Institute $670,380 on September 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to determine the stoichiometry of endogenous voltage-gated potassium channels in the brain. The research addresses fundamental gaps in understanding how ion channels are assembled and regulated in neurons. The work will elucidate the...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on January 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to study the synaptic mechanisms of dopamine-driven reinforcement learning in cortex. The research employs in vivo imaging technology, newly developed opsins and dopamine sensors, and a novel optical brain-machine interface...
- The National Institute of Neurological Disorders and Stroke awarded New York University $550,743 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to fund research into the mechanisms of assembly of endocytic machinery at the periactive zone and its coupling to the presynaptic active zone. The research dissects how the large GTPase dynamin organizes both the active zone, where neurotransmitters are released from...
- The National Institute of Neurological Disorders and Stroke awarded The Rockefeller University $630,609 on July 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate glial cell roles in preserving dendrite integrity following neuronal injury. The research explores how glial cells sense and respond to damage in neuronal dendritic structures and substructures, including dendritic spines and sensory neuron cilia. The...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $230,985 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) for a project examining alternative splicing of ion channels in the human brain. The project profiles the ion channel transcriptome and studies how alternative splicing affects neuronal physiology. Aim 1 combines long-read RNA sequencing and transcript capture technology...
- The National Institute of Neurological Disorders and Stroke awarded The Johns Hopkins University $388,646 on June 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate molecular mechanisms of delta-2 receptor dysfunction in neurological diseases. The research defines how disease-associated mutations perturb GLUD2 (delta-2 type ionotropic glutamate receptor) function and architecture at the molecular level using an...
The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $452,375 on August 10, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to elucidate the molecular architecture and modulation of kainate receptor (KAR) complexes and their auxiliary proteins NETO1 and NETO2. The work combines high-resolution cryo-electron microscopy with electrophysiological techniques to determine the structures of KARs in complex with these auxiliary subunits and to investigate the mechanisms underlying KAR inhibition by endogenous polyamines and pharmacological channel blockers. The research aims to enhance understanding of glutamatergic signaling and support development of therapeutic approaches for neurological disorders associated with KAR dysfunction. Performance is based in New York, New York, with a period of performance from August 10, 2026 through July 31, 2028. This is a Project Grant, an assistance type supporting discrete, circumscribed research projects.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $452.4k | 8/7/26 |