Project Grant R21NS149935
- The National Institute of Neurological Disorders and Stroke awarded the University of Miami $581,794 on September 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into inflammasome activation and its role in the foreign body response triggered by chronically implanted microelectrodes in neural tissue. Microelectrode implants enable neuroprosthetic and neuromodulation technologies for patients with...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Miami $153,500 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to conduct research targeting the NLRP3 inflammasome as a therapeutic link between HIV-1 infection and ischemic stroke. The research employs both in vivo and in vitro approaches to test the hypothesis that HIV-1-induced activation of the NLRP3 inflammasome aggravates ischemic...
- The National Institute of Neurological Disorders and Stroke awarded the University of Colorado a Project Grant totaling $184,506 on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This two-year award, with an ultimate completion date of July 31, 2027, supports research investigating the dual roles of amyloid beta (AB) in central nervous system neuropathogenesis associated with HIV-Associated Neurocognitive Disorder...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $226,500 on August 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize spinal pain and non-pain pathway activity and responses in people with chronic spinal cord injury and neuropathic pain. The research will compare...
- The National Institute of Neurological Disorders and Stroke awarded The Johns Hopkins University $232,938 on February 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to generate critical knowledge on neuronal membrane proteasome-derived peptide signaling in the peripheral nervous system. The research extends prior work on NMP-peptides and their role in peripheral neuron crosstalk and regulation. The award funds proteomics,...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $150,342 to the University of Washington on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of how long-term, closed-loop, epidural spinal cord stimulation affects neuropathic pain symptoms in rats with cervical spinal cord injury. The...
- The National Institute of Neurological Disorders and Stroke awarded the University of Colorado-Denver $723,065 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct a pilot clinical investigation of transcutaneous auricular vagus nerve stimulation paired with motor learning in patients with multiple sclerosis. The research explores whether closed-loop, non-invasive vagus nerve stimulation can enhance myelin...
- The National Institute on Aging awarded the University of Miami $783,407 on August 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a randomized controlled trial of a health promotion intervention for older adults with HIV and documented cardiovascular risk. The study, titled "Strengthening Hearts and Minds: A Health Promotion Strategy for Older Adults with HIV," will enroll 180 adults age 50 and older and randomize them to either the HOPE (Happy Older People Are...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $119,286 on August 18, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the functional roles of microbial metabolites in HIV-associated neurocognitive disorders (HAND). The research integrates metabolomics, metagenomics, in vitro and in vivo assays, and computational approaches to address gaps in understanding...
- The National Institute of Neurological Disorders and Stroke awarded the Regents of the University of Minnesota a cooperative agreement valued at $769,903 on August 1, 2026, to conduct a feasibility and pilot trial of a novel invasive brain stimulation approach for chronic neuropathic pain. The study combines precision functional mapping and individualized neurostimulation targeting the somato-cognitive action network and cingulo-opercular network—two key circuits in pain processing—to address...
The National Institute of Neurological Disorders and Stroke awarded $422,125 to the University of Miami on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct a randomized, waitlist-controlled mechanistic trial characterizing how auricular vagus nerve stimulation modulates HIV-associated peripheral neuropathy in aging adults. The study enrolls 70 adults aged 50 and older with chronic HIV-associated peripheral neuropathy and measures changes in heart rate variability, short interval intracortical inhibition, wind-up ratio, conditioned pain modulation, and serum neuroinflammatory markers (neurofilament light chain, IL-1β, TNF-α, IL-6) following auricular vagus nerve stimulation. The research integrates central and peripheral biomarkers and applies machine learning to develop multivariate biomarker models predictive of individual mechanistic response, focusing on within-person variability rather than group averages. Results will provide foundational data for future mechanistic trials and inform precision neuromodulatory interventions for HIV-associated peripheral neuropathy in older adults. The award recipient is the University of Miami's Office of Research Administration, School of Medicine Division. Work is performed in Miami, Florida. The period of performance runs from September 1, 2026, through August 31, 2028. The assistance type is a Project Grant (R21).
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $422.1k | 9/1/26 |