Project Grant R21NS146733
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $1.878 million to Mayo Clinic Jacksonville on September 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to interrogate alpha-synuclein aggregate-associated proteomes and identify modifiers of Lewy body disease. The project, running through August 31, 2029, employs...
- The National Institute of Neurological Disorders and Stroke awarded the University of Georgia Research Foundation $1,297,188 on May 8, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate neuroinflammatory epitranscriptomic mechanisms in Parkinson's disease. The research examines the role of the ALKBH5 demethylase enzyme in microglial neuroinflammatory responses triggered by alpha-synuclein aggregates, a hallmark...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $627,103 to the Research Foundation For Mental Hygiene, Inc. on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The Research Foundation For Mental Hygiene, Inc., operating through its New York State Psychiatric Institute division, will investigate the role of the adaptive...
- The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic Jacksonville $1.875 million on May 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project investigates enhanced PINK1 kinase activity as a therapeutic strategy against alpha-synuclein pathology and neurodegeneration. The research employs a PINK1 gain-of-function variant (PINK1G411A) to determine whether increasing mitophagy—the selective...
- The National Institute of Neurological Disorders and Stroke awarded the University of Georgia Research Foundation $131,676 on July 27, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research investigating the role of the N6-methyladenosine reader protein YTHDF1 in microglial-mediated neuroinflammation in Parkinson's disease models. The research examines how YTHDF1 dysregulation contributes to alpha-synuclein-induced...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Colorado State University $635,317 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing R01NS151727) to investigate how fibril structure of alpha-synuclein strains affects disease pathogenesis in synucleinopathies. The research addresses disease...
- This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $540,901 on April 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate molecular mechanisms underlying dopamine signaling dysfunction in advanced Parkinson's disease. The research examines how striatal projection neurons become maladaptive during disease progression and why L-DOPA therapy loses efficacy over time. The work focuses...
- Federal Project Grant Award Summary The University of Florida's Division of Sponsored Research received a $422,125 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded August 15, 2025, with a completion date of July 31, 2027. The research focuses on characterizing the role of the DNAJC12 protein in dopamine biosynthesis and physiology through the...
- The National Institute of Neurological Disorders and Stroke, a division of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas Health Science Center at Houston $722,153 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing Project Grant R61NS151436). The recipient will develop and validate a seed amplification assay to detect alpha-synuclein...
The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded $418,489 to the University of Florida on September 1, 2026, for exploration of potential treatments targeting alpha-synuclein in Parkinson's disease under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to develop novel therapeutics for Parkinson's disease, specifically disease-modifying therapies targeting pathological deposits of alpha-synuclein. Current treatments primarily address motor symptoms but do not affect the progression of alpha-synuclein inclusion in the brain. The research focuses on Lewy bodies, a neuropathological hallmark of Parkinson's disease containing aggregated alpha-synuclein protein, approximately 90 percent of which is phosphorylated at serine 129. The University of Florida's Division of Sponsored Research serves as the recipient. Work is performed in Gainesville, Florida. The period of performance runs from September 1, 2026, through August 31, 2028. This is a Project Grant, classified as extramural research funding to support basic research exploring fundamental structure and function of the brain and nervous system, and research to reduce the burden of neurological disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $418.5k | 9/1/26 |