Project Grant R21NS146672
- This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research into the mechanism of PAR1C-mediated AMPA receptor trafficking and synaptic plasticity. The $128,286 award to Rutgers, The State University of New Jersey will investigate how the PAR1C (also known as MARK1) protein regulates the trafficking of AMPA receptors,...
- This Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) will provide $502,981 to the University of Richmond to explore the molecular mechanisms underlying the delivery of AMPA neurotransmitter receptors during the formation of memories. The project aims to identify novel proteins involved in this receptor trafficking process and describe key steps in the membrane fusion events that facilitate receptor insertion at neuronal synapses. This work...
- This $328,000 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research on the phosphorylation-mediated regulation of the activity-regulated cytoskeletal-associated protein (ARC) and its interactions with the AMPA receptor endocytic machinery. The research, conducted by the University of Texas Southwestern Medical Center, aims to investigate the mechanism and regulation of ARC function in AMPA...
- This $396,031 Project Grant award from the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) will support research on G protein-coupled receptor (GPCR) trafficking and signaling in cardiomyocytes and neurons. The key objectives are to map the subcellular distribution of heterotrimeric G proteins, determine how G proteins move or redistribute upon GPCR activation, and develop bioluminescence...
- This $104,298 project grant was awarded on September 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award will fund research to investigate the mechanism of altered synaptic signaling caused by two disease-related variants in the GRIN1 gene, which encodes a critical subunit of NMDAR receptors in the central nervous system. The research...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to determine the molecular mechanisms underlying regulation of the TRPM3 ion channel in the cell membrane. The $410,601 award, effective from August 4, 2025 to June 30, 2030, aims to: 1) Understand the molecular details governing the transition of TRPM3 between closed, open, and desensitized states; and 2) Determine...
- This federal Project Grant award of $812,488 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the conformational dynamics and regulatory mechanisms of the KCNH family of potassium ion channels. The research focuses on understanding the voltage-dependent gating of these channels, including examining the voltage sensor domain and S4 helix, as well as the interactions...
- The federal Project Grant award R15NS137207, valued at $389,851, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research at the Florida Institute of Technology (Florida TECH) to investigate the role of the RPM-1 signaling network in tau protein-related neurodegeneration using a C. elegans tauopathy model. The proposed research...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $147,486 to the University of Washington to investigate the function of a ciliary protein in neural development. The research aims to uncover novel molecular mechanisms involved in synapse formation, particularly as it relates to neurodevelopmental and neurodegenerative...
- This federal Project Grant award for $423,500.00, provided by the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training program), supports research to investigate the mechanisms underlying the organization and function of endoplasmic reticulum-plasma membrane (ER-PM) junctions in mammalian neurons. The research, conducted by the University of Utah, aims to define the signaling interactions and structural organization of ER-PM junctions, with a...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $226,500.00 to the University of Rochester to conduct research on the molecular mechanisms by which Transmembrane AMPA Receptor Regulatory Proteins (TARPs) modulate the gating of AMPA receptors. The research aims to identify the contact sites between the TARP G2 and G8 extracellular loops and the AMPA receptor, as well as elucidate the movement of these loops during receptor activation, desensitization, and superactivation. This work is expected to advance the mechanistic understanding of AMPA receptor and TARP interactions, and glutamate receptor gating, with the project period running from January 1, 2026 to December 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $226.5k | 12/22/25 |