This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $502,981 to the University of Richmond to conduct research on the mechanisms underlying synaptic plasticity and memory formation. The key objectives are to: 1) investigate the role of the SNARE protein SNAP-47 in regulating the fusion of synaptic vesicles and delivery of AMPA-type neurotransmitter receptors to the neuronal cell membrane, and 2) identify novel protein regulators of AMPA receptor trafficking during learning and memory processes. The project will utilize in vitro assays and single-particle cryo-electron microscopy to characterize the molecular mechanisms governing synaptic receptor dynamics. This work will be performed primarily by undergraduate students through mentored research projects and a course-based undergraduate research experience, significantly expanding research training opportunities. The award period is from March 1, 2025 to February 29, 2028.
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