Project Grant R21NS142864
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pennsylvania $203,125 on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to support a two-year research project through February 29, 2028. This R21 exploratory research grant funds an investigation into the neural circuit mechanisms underlying the interaction between chronic pain and sleep disruption,...
- Federal Grant Award Summary The University of Pennsylvania received a $1,137,500 Project Grant awarded on August 1, 2025, under the Trans-NIH Research Support program (CFDA 93.310) from the National Institutes of Health Office of the Director. The award funds a five-year research project extending through May 31, 2030, investigating epigenetic engrams and trans-generational memory mechanisms in planarian flatworms (Schmidtea mediterranea). The research leverages the planarian's unique ability to...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $612,005 Project Grant to the University of Pennsylvania on September 15, 2025, under the Aging Research program (CFDA 93.866) to support a research initiative examining sleep slow-wave activity (SWA) as a potential vulnerability and modifiable risk factor in the progression from chronic stress to accelerated aging and Alzheimer's disease in Black older adults. The research will characterize electroencephalogram...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant of $578,856 under the Aging Research program (CFDA 93.866) on February 15, 2026, with a completion date of January 31, 2031. This award supports scientific research investigating the relationship between sleep and neurodegenerative disease, with the objective of identifying mechanisms through which sleep reinforces homeostatic set-points in neural activity and determining...
- Federal Project Grant Award Summary Pennsylvania State University, operating through Penn State Milton S. Hershey Medical Center, received a $432,802 project grant awarded June 1, 2025, from the National Institute of Neurological Disorders and Stroke under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The two-year award, with completion scheduled for May 31, 2027, supports cross-validation research of gene expression changes associated...
- Federal Project Grant Award Summary The University of Pennsylvania received a $3.2 million Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through July 31, 2029. This research initiative will identify genetic modifiers contributing to phenotypic heterogeneity across the Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal...
- Federal Grant Award Summary The University of Pennsylvania received a $2.82M Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 7, 2025, through July 31, 2029. This research project will investigate the role of TRIM10, a metazoan-specific protein quality control factor, in maintaining TDP-43 (TAR DNA-binding protein 43)...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The University of Pennsylvania a $446,875 Project Grant effective June 1, 2025, through May 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The research project focuses on generating and characterizing a novel NTRK3-FLPO knockin mouse line to enable genetic interrogation of Aβ nociceptors—a previously inaccessible population of...
- Federal Project Grant Award Summary The University of Pennsylvania received a $406,250 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) on June 12, 2025, with a completion date of April 30, 2030. This five-year research initiative investigates how circadian and metabolic rhythms regulate cell maturation and maintain mature cellular phenotypes. The research employs in situ multimodal...
- Federal Project Grant Award Summary The University of Pennsylvania received a $664,458 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective September 1, 2025, through August 31, 2030. The research project focuses on developing and validating an optical cerebral hemodynamic monitoring system for detecting large vessel occlusion (LVO) in...
The University of Pennsylvania received a $243,750 Project Grant award dated February 11, 2026, from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports research through December 31, 2027, to advance understanding of sleep and wake regulation mechanisms in the brain. The research will deliver single-nucleus gene expression and chromatin accessibility profiling analyses of the murine hypothalamus, employing single-nucleus RNA sequencing (snRNA-seq) and complementary molecular techniques to identify and characterize neuronal heterogeneity associated with sleep and wakefulness states. Specifically, the project will generate comprehensive molecular and functional characterization of hypothalamic neurons involved in sleep-wake regulation, comparing gene expression patterns across multiple physiological states including natural sleep, wakefulness, and sleep deprivation-induced recovery sleep. The research will identify novel signaling mechanisms underlying sleep homeostasis, particularly examining expression changes in receptor genes and other molecular markers in sleep-active neuronal populations. Deliverables include peer-reviewed research findings, characterized datasets of gene expression and chromatin accessibility patterns, and mechanistic insights into neuronal circuits controlling sleep and wakefulness that may inform future therapeutic development for sleep disorders and neurological conditions.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $243.8k | 2/10/26 |