This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders supports research to characterize the structure, dynamics, and signaling of G Protein-Coupled Receptors (GPCRs). The total award amount is $627,837.00 and the project period runs from May 15, 2024 to April 30, 2032.
The research, conducted by The Leland Stanford Junior University, aims to...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $563,934 to Tufts University School of Medicine to conduct research studies on G-protein coupled receptors activated by neuroactive steroids. The key objectives are to: 1) evaluate the effects of neuroactive steroids on intracellular signaling via distinct membrane progesterone receptor (MPR) subtypes; 2) assess the role of the MPRD...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded Emory University a $430,375 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to study disease-associated mutations and ligand activation of the adhesion G protein-coupled receptor ADGRB2. The key objectives are to:
Investigate newly identified patient mutations in the ADGRB2 gene that are associated with spastic paraparesis and other neurological...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $885,128 to Duke University to conduct research on the structure, function, and pharmacology of sensory receptor ion channels in somatosensory neurons. The research aims to gain a molecular-level understanding of the design principles governing somatosensation and nociception,...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $404,340 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Georgia Research Foundation, Inc. The project aims to develop a novel method using split fluorescent protein tags to map the localization of neurotransmitter receptors within neural circuits in the Drosophila model organism. This work will provide crucial new insights into...
Emory University received a $430,375 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to elucidate the subcellular dynamics of ubiquitination, a key biological process regulating synaptic function and neuronal health, using advanced single-molecule imaging techniques. The research aims to uncover new mechanisms by...
This $1,830,581 Project Grant was awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports an in-depth characterization of the mode of action of RAPIREON, a novel macrocycle molecular glue that selectively activates the nuclease activity of IRE1 - a key component of the unfolded protein response (UPR) pathway involved in...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $431,676.00 to support research on the molecular mechanisms that impact drug bioavailability across the blood-brain barrier in patients with drug-resistant epilepsy. The research aims to study the role of the glucocorticoid receptor (GR) in regulating cytochrome P450 and...
This federal Project Grant award of $364,448.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) focuses on investigating the neural functions of glycoprotein sialylation. The research aims to reveal sialylation-mediated mechanisms of glia-neuron coupling, elucidate the role of sialylation in promoting neuronal viability and resistance to oxidative stress, and...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides funding of $543,337.00 over the period of January 1, 2025 to December 31, 2029 to conduct research on long-distance regressive signaling underlying the sculpting of the nervous system during development. The research aims to characterize the features of the p75...