This $9,237,770 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Drug Use and Addiction Research Programs (CFDA 93.279), aims to gain integrated mechanistic insights into the biological processes that contribute to chronic post-surgical pain (CPSP) and understand the heterogeneity of CPSP phenotypes. The grant supports a multi-institutional research program led by Washington University that brings together expertise in pain...
The federal Project Grant award R01NS136997, totaling $560,934.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to define the temporal patterns and characteristics of local field potential (LFP) oscillations in the primary somatosensory cortex (S1) of mice, and correlate these LFP oscillations to underlying neural activity and...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $664,772 to support research on a novel, non-opioid analgesic mechanism for treating high-impact chronic pain. The primary awardee, The University of Texas Southwestern Medical Center, will investigate the signaling pathways involving the neurotensin receptor 2 (NTSR2)...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 5-year, $453,104 Project Grant (CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders) to The University of Texas Southwestern Medical Center. The grant will fund research to explore the role of two key subtypes of spinal projection neurons, TACR1-expressing and GPR83-expressing neurons, in transmitting pain signals to the brain and their potential as therapeutic targets for...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,314,276.00 in funding to Emory University to develop novel methods for selectively stimulating nociceptors and measuring nociceptive-specific brain activations. The project aims to overcome limitations in current experimental pain testing by identifying skin regions devoid of innocuous warm fibers, allowing for unbiased...
This federal Project Grant award in the amount of $603,406 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports research by the Research Triangle Institute (RTI International) to develop and evaluate GPR139 antagonist compounds as potential adjuvants to morphine for the treatment of pain. The key products and services to be delivered...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on exploring the unknown function of the LRRC55 protein in pain management. The $444,125 award to Duke University will fund a 2-year research project to: 1) delineate LRRC55's roles in chronic pain behaviors using knockout mice; 2) quantify functional changes in LRRC55 expression in dorsal root ganglion and spinal cord...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $675,107 to Northeastern University to conduct research on the development of non-opioid, non-addictive analgesics for treating neuropathic pain. The project aims to design and synthesize novel "dualsteric modulators" that can act as both non-psychoactive...
This $2,068,842 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to dissect the role of prefrontal cortex dynorphin circuits in modulating different pain states. The research aims to identify pain-induced adaptations in the prefrontal cortical dynorphin/kappa-opioid receptor system and its influence on pain-induced maladaptive behavior and nociception. Through...
This $2,569,851 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Abuse and Addiction Research Programs (CFDA 93.279), supports research to investigate how the PD-L1/PD-1 immune checkpoint pathway controls physiological and pathological pain, as well as opioid analgesia, through neuronal, immune, and glial mechanisms. The project aims to validate the actions of PD-L1 and the checkpoint inhibitor nivolumab on neuroinflammation and...