The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $427,625 Project Grant (CFDA 93.853) to the University of Wisconsin-Madison to profile the cell type-specific ubiquitome in Ube3a mutant mice. The goal is to systematically identify differentially ubiquitinated proteins, potentially Ube3a substrates, in excitatory and inhibitory neurons at different developmental stages. By using a specialized Cre-dependent ubiquitin tagging mouse line, the researchers will visualize cell type-specific and age-specific ubiquitination of Ube3a substrates and generate comprehensive ubiquitome profiles. This work aims to elucidate Ube3a's varying functions across cell types and ages, enhancing understanding of its role in Angelman syndrome and advancing towards effective treatments. The award period is from June 1, 2025 to May 31, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $427.6k | 5/27/25 |