This federal Project Grant award of $221,120.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to improve neural progenitor (NP) survival and migration for the treatment of neurodegenerative diseases and brain injuries. The project investigates the potential of adult central nervous system (CNS) endothelial cells to express developmental...
This Project Grant award for $2,398,590.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of brain microcirculation and capillary endothelial cell energetics in the development of vascular cognitive impairment and dementia (VCID) observed in Alzheimer's disease (AD) and AD-related dementias. The...
This Project Grant award of $2,156,000.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports a research project to develop and validate non-invasive neuroimaging methods for quantifying brain oxygen availability, pH, and carbon dioxide levels. The goal is to better understand the relationship between cerebral blood flow, neuronal metabolic demands, and the regulation of waste products, in order to identify the underlying causes of brain...
This Project Grant award of $373,778, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support the establishment of a novel vasculature database and analytical platform for mouse brain vasculature. The award aims to develop advanced topology-preserving vessel segmentation methods, novel topological features, topological mappings, and visual analytic...
This federal Project Grant award of $377,875 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to develop a "one-two punch" strategy using engineered extracellular vesicles (EVs) to protect the blood-brain barrier (BBB) and improve outcomes in stroke. The primary goals are to: 1) deliver ATP5A and HSP27 proteins via the EVs to increase endothelial...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $2,503,949 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Rockefeller University. The grant, awarded on May 1, 2025, supports a research project titled "Applying RNA Logic in Space and Time to Neurologic Disease". The project aims to develop new techniques and concepts to discover therapeutic targets for neurological diseases by studying...
This $536,617 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the mechanisms of neural regeneration in model organisms. The primary awardee, Oregon Health & Science University, will conduct experiments using planarians and zebrafish to investigate how adult neural stem cells can regenerate neural tissue and restore...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), will provide $123,616.00 to investigate the role of the blood-brain barrier in the trafficking of prenatal liver-derived immune cells into the brain. The research aims to elucidate the cellular and molecular development of the blood-brain barrier and its impact on cellular...
This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...