The federal Project Grant award R21NS140988, totaling $435,875.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This award, with a performance period from Sep 20, 2024 to Aug 31, 2026, will support research by the Trustees of Indiana University (the Awardee) to reveal the functional complexity of cortical vasoactive intestinal polypeptide (VIP) interneurons and their role in processing salient signals like aversive stimuli and rewards within local microcircuits. The research aims to uncover the heterogeneity of spike responses generated by genetically defined dis-inhibitory VIP interneurons and their downstream effects on postsynaptic partners, which may provide insights into the pathological operation of cortical circuits linked to attention and salient signal detection deficits observed in conditions like schizophrenia, autism, and ADHD.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $435.9k | 9/20/24 |