This Project Grant award of $390,178 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to identify molecular, cellular, and electrical biomarkers for diagnosing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The key product will be a matrix of biomarkers derived from investigating gene expression, functional pathways, and electrical characteristics of single skeletal muscle mononucleated cells from ME/CFS patients compared to healthy individuals. The research will utilize single-cell RNA sequencing, impedance cytometry, and machine learning analysis. Collaborators from the University of G. d'Annunzio Chieti-Pescara and the University of Padova in Italy will contribute expertise in muscle tissue extraction, cell characterization, and single-cell genomics. The award has an ultimate completion date of Aug 31, 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $390.2k | 9/3/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
54511378002S | Universita\' Degli Studi G. D\'Annunzio DI Chieti-Pescara | Project Grant R21NS139044 | $58.0k | 3/12/25 | |
54511378001S | Universita\' Degli Studi DI Padova | Project Grant R21NS139044 | $58.0k | 1/23/25 |