This $684,451 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports comprehensive research to advance understanding and treatment of Parkinson's disease (PD). The project aims to: Identify PD progression subtypes through integrative modeling of longitudinal clinical, transcriptomic, and neuroimaging data from the Parkinson's Progression...
The federal Project Grant award of $173,140 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to elucidate the role of neural activity in the degeneration of midbrain dopamine neurons in Parkinson's disease. The project aims to utilize novel mouse models to chronically manipulate the activity and dopamine metabolism within dopamine neurons,...
This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, provides $245,847.00 to Duke University to investigate the role of the Integrated Stress Response (ISR) pathway in dopamine neurons and its implications for Parkinson's disease. The project, titled "The ISR Pathway in Dopamine Neurons: Perpetrator or Protector in Parkinson's Disease," aims to examine ISR states in dopamine neuron subclasses in...
This federal Project Grant award of $682,493 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to elucidate the role of aberrant histone acetylation in the pathogenesis of Parkinson's disease (PD) and related synucleinopathies. The primary goal is to leverage a human pluripotent stem cell-based discovery platform to investigate how disruption of...
This Project Grant award, valued at $635,430.00 and effective from July 22, 2024 to June 30, 2029, is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The project aims to advance the understanding of how regulatory genetic variation contributes to the risk and progression of Parkinson's disease (PD). Key objectives include defining the chromatin and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $616,200.00 to support research into the influence of neuromelanin on single dopaminergic neurons in Parkinson's disease. The primary objective is to leverage expertise across three established labs to explore how progressive neuromelanin accumulation in dopamine...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $414,191 to Drexel University to investigate the interplay between polymorphic alpha-synuclein (α-syn) fibril conformation and cell-dependent pathology. The goal is to elucidate the molecular mechanisms underlying conformation-dependent neuropathology in...
This National Institute of Neurological Disorders and Stroke (NINDS) Project Grant award, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $231,255 to The Trustees of the University of Pennsylvania from July 2024 through June 2029. The grant supports research to identify the tissue source and pathogenic properties of alpha-synuclein protein strains found in the plasma of individuals with Parkinson's disease. The project aims...
This $741,976 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate the role of interleukin-13 (IL-13) and its receptor IL-13RA1 in regulating the survival of dopaminergic neurons and potentially contributing to Parkinson's disease pathogenesis. The research aims to determine the molecular and cellular mechanisms by...