This $444,125.00 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will be used by the University of California, San Francisco (UCSF) to conduct research on the brain maturation-dependent mechanisms underlying hemorrhagic transformation after delayed reperfusion in perinatal and childhood ischemic stroke. The key objectives are to: 1) confirm the extent of hemorrhagic transformation, blood-brain barrier disruption, and neuroinflammation in models of late reperfusion following transient middle cerebral artery occlusion in neonatal and juvenile mice, and 2) determine how disruption of specific chemokine signaling pathways affects these outcomes in the context of postnatal brain maturation. This proof-of-principle research aims to provide evidence-based guidance on the safety of delayed recanalization in infants and children who have suffered an ischemic stroke.
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