Project Grant R21MH141572
- Federal Grant Award Summary The National Institute of Mental Health awarded a $127,557 Project Grant to the University of California, Davis under the Mental Health Research Grants program (CFDA 93.242) for the period September 25, 2025 through September 24, 2027. This F31 Predoctoral Fellowship supports integrated multidisciplinary training in cellular and molecular neurobiology and immunology, with the primary deliverable being doctoral-level research investigation into brain aging processes in...
- Federal Grant Award Summary The University of California, Davis received a $442,750 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) for the period July 1, 2026 through June 30, 2028. This award funds fundamental research investigating synaptic plasticity and signaling mechanisms in a mouse model of 22q11.2 Deletion Syndrome (22Q11.2DS), the most common chromosomal microdeletion in humans affecting approximately 1...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded $150,104 to The Regents of the University of California, San Francisco under the Mental Health Research Grants program (CFDA 93.242) on March 1, 2026, with an ultimate completion date of October 31, 2028. This Project Grant supports basic neuroscience research investigating how myelin plasticity—the dynamic changes in myelin sheaths produced by oligodendrocytes—influences neural circuit dynamics required...
- Federal Project Grant Summary The National Institute of Mental Health (NIMH) awarded the University of California, Davis $442,750 under the Mental Health Research Grants program (CFDA 93.242) on April 1, 2026, to develop statistical methodologies for predicting individualized intervention effects in clustered and longitudinal datasets. The two-year project, scheduled for completion on March 31, 2028, addresses a critical gap in precision medicine by creating novel statistical and machine...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded the Regents of the University of California, San Francisco a Project Grant of $832,307 under the Mental Health Research Grants program (CFDA 93.242), with an award date of April 24, 2026, and ultimate completion date of December 31, 2030. This research initiative, titled "Genetic Control of Basal Telencephalic Development," aims to identify transcriptional and epigenetic mechanisms that control...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of California, San Francisco a $800,384 Project Grant on March 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support basic neuroscience research investigating prefrontal-hippocampal neural circuitry. The project, which runs through December 31, 2030, will deliver fundamental research elucidating the molecular and functional mechanisms of long-range GABAergic...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a Project Grant of $121,933.00 to the University of California, San Diego under the Mental Health Research Grants program (CFDA 93.242) for the period of June 1, 2025 through May 31, 2027. This research project will deliver scientific investigation into compartment-specific synaptic organization and plasticity in layer 2/3 pyramidal neurons during learning in behaving animals. The research employs cutting-edge...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $489,732 Project Grant to the University of California, Davis, effective July 1, 2026, through June 30, 2031, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This award funds basic neuroscience research investigating the molecular mechanisms that regulate extrasynaptic AMPA receptors (AMPARs) and their transmembrane auxiliary...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $117,747 Project Grant (CFDA 93.242: Mental Health Research Grants) to The Regents of the University of California, San Francisco, effective May 22, 2026, through April 30, 2028. The award funds basic neuroscience research investigating the neural computations underlying flexible behavioral control and problem-solving. The project combines large-scale electrophysiology with closed-loop optogenetics in...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded J. David Gladstone Institutes a Project Grant totaling $2,177,199 under the Mental Health Research Grants program (CFDA 93.242), effective September 1, 2025, through August 31, 2027. This two-phase, milestone-driven research initiative aims to develop and validate a novel humanized microglia-neural cell (HUMGN) mouse model that incorporates human microglia, neurons, and astrocytes differentiated from induced...
The National Institute of Mental Health (NIMH) awarded University of California, Davis a $437,870 Project Grant under CFDA 93.242 (Mental Health Research Grants) effective July 1, 2026, through June 30, 2028, to conduct exploratory research investigating the mechanisms of satellite oligodendroglia-neuron interaction during postnatal brain maturation. The research will employ spatial transcriptomics and genetic approaches to identify neurons receiving oligodendroglia-derived nuclear and ribosomal material and explore the triggers of oligodendroglia-neuron material transfer (ONMT) in both healthy developing cortex and neuroinflammatory conditions. The study aims to elucidate cellular mechanisms underlying healthy brain development with implications for understanding disruptions associated with autism, cerebral palsy, epilepsy, and other neurological disorders. The project deliverables include single-cell transcriptional profiling data of satellite oligodendroglia-neuron nuclear pairs, mechanistic insights into the role of direct internuclear contact in material transfer during neuronal maturation, and identification of molecular triggers and conditions that regulate ONMT. By advancing understanding of glial-neuronal interactions critical to synapse formation, synaptic pruning, and axonal myelination, this research will provide foundational knowledge to support development of therapeutic interventions promoting healthy brain maturation and preventing or ameliorating neurodevelopmental disorders.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $437.9k | 6/22/26 |