The National Institute of Mental Health (NIMH) awarded a $514,178 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Laureate Institute For Brain Research, LLC, a non-profit research organization in Tulsa, Oklahoma. The award will fund a 5-year research project to investigate the mechanistic relationship between brain circuit function and negative valence system behaviors, such as anhedonia and rumination, in individuals with treatment-resistant depression. The...
The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Intelligent Imaging Innovations, Inc. (3i), a for-profit manufacturer of advanced microscopy equipment and software based in Denver, Colorado. The two-year grant, awarded on January 1, 2025, seeks to establish the feasibility of combining recent advances in optical techniques to produce a commercial instrument that enables large-scale, all-optical...
The National Institute of Mental Health (NIMH) awarded a $282,625 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Rector & Visitors of the University of Virginia (UVA) to develop a novel non-invasive strategy for degrading perineuronal nets (PNNs) in the brain to treat excessive repetitive behavior, a common feature of conditions like obsessive-compulsive disorder, autism, and schizophrenia. The project will use magnetic resonance-guided, low-intensity focused ultrasound...
The National Institute of Mental Health (NIMH) awarded a $156,656 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The General Hospital Corporation (doing business as Massachusetts General Hospital) to advance functional MRI (fMRI) techniques for mapping brain activity across cerebral cortical layers. The project aims to validate and benchmark a "linescan fMRI" method that can achieve higher spatial resolution than conventional laminar fMRI, enabling...
The National Institute of Mental Health (NIMH) awarded a $1,453,943 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the University of California, Los Angeles (UCLA) for the period of June 1, 2025 to May 31, 2028. The grant will fund the development of an integrated, portable sensor suite to concurrently record neural activity, physiological arousal, motor signals, and physical interactions in social environments. The project aims to track neuro-behavioral attention...
The National Institute of Mental Health (NIMH) awarded a $904,100 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Lovelace Biomedical Research Institute in Albuquerque, New Mexico. The grant, awarded on May 5, 2025, will fund a longitudinal study to develop algorithms that predict mental health functioning and related outcomes, such as recidivism and substance use relapse, in incarcerated women. The research will utilize multimodal data, including psychosocial,...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $701,011.00 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the underlying mechanisms of low-intensity focused ultrasound (LIFU) neuromodulation. The project aims to systematically map the parameter space of LIFU's impact on...
This federal Project Grant award of $1,920,113, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports a research project titled "Narrowing the Mechanistic Gap for Anterior Prefrontal Cortex Function". The project aims to conduct a deep dive on the anatomy and function of the anterior lateral prefrontal cortex (ALPFC) region of the brain, which has been implicated in various mental health disorders such as...
The National Institute of Mental Health (NIMH) awarded a $744,121 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Leland Stanford Junior University (Stanford University) to develop foundation models (FMs) specifically designed for large, open-source task-free fMRI datasets. The project aims to harness the transformative potential of FMs in the fields of clinical neuroscience and psychiatry to investigate multiple prevalent psychiatric disorders, predict clinical symptom...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 - Mental Health Research Grants provides $638,872 to The Feinstein Institutes for Medical Research to conduct research on "Elucidating Reward Network Modulation in Medial Forebrain Bundle Deep Brain Stimulation for Treatment Resistant Depression". The goal is to use brain imaging to understand how deep brain stimulation of the medial forebrain bundle impacts the brain's reward processing...