This $392,500 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program will support research on the developmental origins of mental illness, with a focus on the hypothalamus and its role in motivated behaviors. The principal investigator at the University of California, Irvine aims to: Develop normative brain imaging-based measures of hypothalamic structure and connectivity from birth to adulthood using large-scale...
This $2,055,184 Project Grant award from the National Institute of Mental Health (NIMH) under CFDA program 93.242 - Mental Health Research Grants is funding research at the University of California, Los Angeles (UCLA) to investigate the role of prefrontal dopamine circuits in threat avoidance learning. The research aims to measure and manipulate dopamine dynamics in the medial prefrontal cortex to understand how dopamine modulates neural activity patterns required for flexibly learning to...
The University of California, Los Angeles (UCLA) received a $2,686,858 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The purpose of this award is to conduct research on the neural circuits and mechanisms underlying social buffering, which refers to how social interactions can help mitigate negative emotional states induced by...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,453,943 to the University of California, Los Angeles (UCLA) to develop an integrated, portable sensor suite for concurrent recording of neural activity, physiological arousal, motor signals, and physical interactions in social environments. The objective is to optimize synchronization and portability of these multi-modal sensors while...
This federal Project Grant award of $606,029.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the neurocircuitry underlying motivated reward-seeking behavior in response to stress. The key goals of the research are to: 1) Determine if a subpopulation of GABAergic neurons in the medial habenulo-interpeduncular (MHB-IPN) axis...
This $682,470 Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) supports research by the University of California, Los Angeles (UCLA) to elucidate the regulation of cell fate specification in the development of the human cortex. The goal is to better understand the etiology of neurodevelopmental disorders. The research will leverage recent advances in single-cell characterizations of the developing human cortex to identify novel...
The National Institute of Mental Health awarded a three-year Project Grant totaling $3,618,976 to the University of California, Los Angeles under the Mental Health Research Grants program (CFDA 93.242) to develop in situ single-cell multi-omic and morphological profiling methods for mammalian brains. Specifically, the university will work to design photonic-indexing sequencing strategies to spatially barcode tissue with single-cell resolution, integrating techniques such as PI-ATAC-seq and...
The National Institute of Mental Health (NIMH) awarded a $649,965 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Regents of the University of California, San Francisco (UCSF) to study the mechanisms and functions of amygdala-hippocampus beta synchrony. The research aims to identify specific connections between the basolateral amygdala (BLA) and ventral hippocampus (VHPC) that generate beta-frequency synchronization, and to understand how this synchronization dynamically...
The National Institute of Mental Health (NIMH) awarded a $782,271 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of California, Los Angeles (UCLA) to advance precision psychiatry through a learning health care system framework. The key products and services to be delivered under this 5-year grant include: Developing a nationwide federated transfer-learning platform for generalizable and bias-aware diagnostic algorithms. Integrating advanced genomic analysis methods...
The National Institute of Mental Health (NIMH) awarded a $431,750 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of California, Irvine (UC Irvine) to investigate the role of the medial striatum in spatial sequence learning and its interaction with the hippocampus. The two-year study, running from September 1, 2023 to August 31, 2025, aims to evaluate how the dorsomedial striatum contributes to the disambiguation of repeated spatial traversals that occur in distinct...