Project Grant R21HL184210
- Federal Project Grant Award Summary Georgia TECH Research Corp received a $1.113 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 3, 2025, with a completion date of April 30, 2029. This research initiative will develop and evaluate engineered biomaterials and targeted lipid nanoparticle delivery systems designed to enhance lymphatic regeneration and improve outcomes for lymphedema...
- Federal Project Grant Award Summary William Marsh Rice University received a $491,029 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 20, 2025, with a completion date of April 30, 2029. The award funds development of a bioengineered lymphatic regenerating platform designed to treat breast cancer-related lymphedema (BCRL), a chronic condition affecting approximately 40% of breast cancer...
- Project Grant Summary The University of Texas at Austin received a $1.356 million Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 5, 2025 through May 31, 2029. The project focuses on the optimized development of novel leaflet biomaterials for replacement heart valves (RHV), addressing critical limitations in current bioprosthetic heart valve (BHV) technology. Current BHV designs,...
- Federal Grant Award Summary Texas A&M Engineering Experiment Station received a $395,695 Project Grant award dated August 1, 2025, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), administered by the National Institute of Biomedical Imaging and Bioengineering (NIBIB). The four-year project, extending through July 31, 2029, will develop novel multi-modal ultrasound imaging methods designed to serve as predictive markers...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Virginia a $950,550 Project Grant effective April 1, 2026, through February 28, 2033, under the Cardiovascular Diseases Research program (CFDA 93.837). This grant supports development and validation of advanced magnetic resonance imaging (MRI) technologies to visualize sodium accumulation and lymphatic system physiology in patients with lymphatic disease. The research delivers three...
- Federal Grant Award Summary South Dakota State University received a $452,869 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on April 20, 2026, with a completion date of January 31, 2031. This research initiative focuses on elucidating the role of intraflagellar transport (IFT) proteins—specifically IFT74 and IFT20—in regulating lymphatic endothelial cell (LEC) primary cilia and their function...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $1.29M project grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded September 1, 2025, with completion targeted for August 31, 2028. The project develops advanced imaging and analysis tools to enhance lymphoscintigraphy (LSG), the current gold...
- Summary of Federal Project Grant Award The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $414,996 to Indiana University Indianapolis, with an award date of August 15, 2025 and ultimate completion date of May 31, 2030, under the Cardiovascular Diseases Research program (CFDA 93.837). This research project investigates the mechanisms of junctional proteins in post-surgical lymphedema, a chronic condition affecting an estimated 5–10 million Americans. The...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $234,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 15, 2025 through July 31, 2027. The research will investigate the force transduction mechanisms of leukocyte function-associated antigen-1 (LFA-1), a critical CD18 integrin that mediates immune cell adhesion, migration, and...
- Federal Grant Award Summary The University of Texas Health Science Center at Tyler received a $499,585 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 15, 2025, with completion targeted for June 30, 2027. This preclinical research project delivers investigational therapeutic development for treating empyema (pleural sepsis), a condition with rising incidence and mortality rates. The research...
Texas A&M Engineering Experiment Station received a $404,424 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded May 1, 2026, with completion targeted for April 30, 2028. The grant supports development of an extracellular matrix (ECM)-based lymphatic patch with valved pre-collectors designed to restore lymphatic function and enable unidirectional lymph flow. The research integrates optogenetics, biomaterials, and bioengineering to create bioengineered lymphatic tissue with functional valves—a technological advancement addressing critical gaps in current regenerative approaches that promote lymphangiogenesis but fail to engineer larger lymphatic vessels with competent valve structures necessary for sustained drainage. The project deliverables include: (1) engineering a three-dimensional lymphatic patch with valved pre-collectors and evaluating valve formation and maturation under physiological flow conditions using an innovative perfusion bioreactor system; and (2) demonstrating host integration of the lymphatic patch and its ability to restore lymph flow and reduce tissue swelling in a mouse model of lymphedema. This interdisciplinary effort leverages expertise in tissue engineering, optogenetic engineering, and lymphatic physiology to produce an implantable therapeutic solution for lymphedema treatment with potential applications for future lymphatic-related disorders.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $404.4k | 5/4/26 |