This $305,000 project grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a clinical decision support system (CDSS) called Sepsis FLO. The CDSS is designed to precisely guide blood volume diagnosis and treatment for sepsis patients. Key activities include: 1) Developing an alpha prototype of the CDSS through user-centered design; 2) Validating three functional...
This $598,228 Project Grant awarded by the National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), supports research to investigate the role of endoplasmic reticulum autophagy (ER-phagy) in the host immune response during sepsis. The grant aims to: 1) define the impact of macrophage ER-phagy on NLRP3 inflammasome activation and lung injury in sepsis; 2) elucidate the molecular mechanisms linking ER-phagy to NLRP3...
This Project Grant, awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a unique antimicrobial vascular catheter to prevent catheter-related bloodstream infections (CRBSI). The $272,702 award, effective September 1, 2023, with a completion date of February 29, 2024, will support research and development efforts to create an intravascular catheter with inherent long-lasting antiseptic properties. The...
This $1,165,298 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop novel nanopore- and click-chemistry-based approaches for rapid, culture-independent detection of sepsis-causing pathogens directly from blood samples within 2 hours. The project will engineer nanopore biosensors and multiplex click chemistry-amplified nanopore sensing to target proteomic biomarkers like outer...
This $455,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports a research program to decrease pediatric sepsis mortality. The key products and services to be delivered include: Development of an AI-guided early sepsis identification tool to enable timely diagnosis and treatment. Conducting sepsis phenotyping and creating digital twin patient models to predict personalized...
This Project Grant from the National Heart, Lung and Blood Institute, part of the Department of Health and Human Services, provides $920,176 under the Cardiovascular Diseases Research program to develop a smart aspiration catheter with fiber optic pressure sensors for mechanical thrombectomy procedures to treat acute ischemic stroke. The catheter will be designed, prototyped and validated at Worcester Polytechnic Institute to provide real-time data to interventionalists on the interaction...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $310,170 to Cathpro Technologies, LLC to develop an innovative luminal insert for vascular catheters. The goal is to create a product that combines anti-infective and anti-thrombotic technologies to effectively reduce intraluminal infections and thrombotic occlusions in catheters. The funding will support feasibility studies to optimize...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $503,496 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to conduct research on acute respiratory failure risk among patients with hospital-onset sepsis. The key objectives of this 5-year project are to: 1) identify clinical presentation phenotypes of hospital-onset sepsis, 2)...
This $312,974.00 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of accurate, efficient, and interpretable multi-modal foundation models for the early detection of sepsis. The award, effective February 1, 2025 through January 31, 2030, will be carried out by the University of California, San Diego (UCSD) to address the critical challenge of early sepsis...
The federal Project Grant award of $579,604.00 from the National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), is for the "OPTIMIZING VASOPRESSOR DELIVERY IN EARLY SEPSIS" research project. This award falls under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), which supports comprehensive scientific research to understand, prevent, diagnose, and treat cardiovascular conditions. The University of Michigan, a...