Project Grant R21HL172119
- This $193,896 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to identify clinical markers that can serve as surrogates for right ventricular-pulmonary artery (RV-PA) coupling, a metric that quantifies right ventricular adaptation in pulmonary arterial hypertension (PAH). The grantee, The Johns Hopkins University, will leverage a unique dataset of over 100 PAH patients to 1) develop a multivariable model...
- This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $186,408 to the University of Washington to develop robust models that identify patients at high risk for persistent hypoxemic respiratory failure (HRF). The goal is to improve the ability to distinguish patients with persistent HRF early, which is critical for enrolling the highest-risk patients in clinical trials for new HRF...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $641,544 to the University of North Carolina at Chapel Hill to develop enhanced machine learning tools for complex data evaluation and integration in advancing health outcomes related to heart, lung, blood, and sleep (HLBS) disorders. The project aims to: 1) propose novel machine learning methods for adjusting complex confounding...
- This federal Project Grant award, totaling $753,813 and provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research to develop novel machine learning techniques for predicting cardiovascular outcomes in patients with clonal hematopoiesis of indeterminate potential (CHIP). The key goals are to use cardiac MRI imaging and genomic data to: 1) Develop a machine learning model to accurately identify CHIP patients and predict their risk...
- This Project Grant award of $248,431.00, granted by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), supports research at The Johns Hopkins University to investigate the role of microenvironment mechanics in regulating cardiac myofibroblast plasticity. The research aims to leverage human induced pluripotent stem cell-derived cardiac fibroblasts, engineered biomaterials, and single-cell multiomics platforms to elucidate...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $144,989 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop, train, and test deep generative models using computed tomography (CT) images to predict lung injury progression and treatment responses in patients with acute respiratory distress syndrome (ARDS). The goal is to leverage artificial intelligence and image...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $657,308 to The Children's Hospital of Philadelphia (CHOP) to conduct research on the CXCL12 signaling axis and its role in pulmonary arterial heterogeneity, development, and disease. The key objectives of this 12-month project are to: 1) define the spatiotemporal role of CXCL12 signaling in pulmonary vascular development, 2)...
- This $146,013 Project Grant award from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) will be used by The Medical College of Wisconsin, Inc. to establish a large patient cohort leveraging electronic health record and administrative claims data to determine the risks of cardiopulmonary and renal end organ complications and factors associated with frequent acute care use among individuals with sickle cell disease. The award period...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $586,637 to the University of New Mexico (UNM) to conduct research into the mechanisms of immune dysregulation that contribute to the development of hypoxic pulmonary hypertension (PH). The research aims to identify how chronic hypoxia causes a decrease in regulatory T cells (Tregs) and promotes the development of self-reactive T helper 17 (Th17) cells that target...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $654,207 to The Johns Hopkins University to conduct research on the role of thrombospondin-1 (TSP-1) in heart failure with preserved ejection fraction (HFPEF). The goal is to identify the mechanisms by which TSP-1 activation modulates cardiac fibrosis and remodeling in HFPEF, particularly in relation to sex-specific...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $245,624 to The Johns Hopkins University to conduct research aimed at using unsupervised machine learning to identify distinct clusters of systemic sclerosis patients with pulmonary hypertension. The research will leverage data from the NHLBI-funded Pulmonary Vascular Disease Phenomics Program and the Johns Hopkins Pulmonary Hypertension Registry. The goals are to better classify pulmonary hypertension subtypes in this patient population and evaluate outcomes like transplant-free survival and hospitalization rates across the newly identified patient clusters. This work has the potential to improve treatment selection for individuals with this complex cardiovascular condition.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/3/25 | ||
| Not listed | $245.6k | 8/13/25 |