Project Grant R21HG014313
- Federal Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded a $2.8 million Project Grant to The Washington University (Office of Sponsored Research Services) effective September 1, 2025, through August 31, 2029, under the Human Genome Research program (CFDA 93.172). This award supports the development and implementation of a high-throughput, genome-integrated reporter gene system designed to systematically measure enhancer activities at multiple fixed distances...
- Federal Project Grant Award Summary New York University School of Medicine received a $3.13 million Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 5, 2025 through July 31, 2029. This award supports fundamental biomedical research investigating positional epigenetic memory and HOX (Homeobox) gene expression—critical mechanisms governing body axis patterning and cellular...
- Federal Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded the University of California Santa Cruz $633,116 under the Human Genome Research program (CFDA 93.172) on September 26, 2025, for a project extending through June 30, 2029. This project grant advances comparative genomics through three interconnected research aims. Aim 1 develops scalable computational infrastructure to accommodate rapidly growing vertebrate genome datasets, including a new column-based...
- Federal Project Grant Award Summary The University of California, San Diego received a $694,900 Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded on August 11, 2025, with completion scheduled for June 30, 2029. This project will deliver fundamental research and computational methodologies for identifying causal enhancer variants—genetic changes within enhancer elements that regulate gene expression timing,...
- Federal Project Grant Award Summary Yale University received a $248,823 Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), effective May 1, 2026 through April 30, 2029. This award supports the development of integrative computational models to elucidate the functional consequences of nuclear DNA organization on gene regulation and human health. The project delivers three primary research outputs: (1) novel deep...
- Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded the University of Washington a $2.22 million Project Grant under the Human Genome Research program (CFDA 93.172) on September 10, 2025, with completion targeted for August 31, 2029. The project, titled "Sequence-to-Function Models for Mechanistic Investigations of Personal Genomes," develops advanced deep learning models to predict gene expression consequences directly from DNA sequences....
- Federal Project Grant Award Summary The University of Chicago received a $581,259 Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), effective August 20, 2025, with a completion date of June 30, 2029. This award supports the development of novel methodologies for transcriptomic characterization of membraneless organelles (MLOs)—subcellular structures ranging from 1-200 nanometers to several microns that organize...
- The National Human Genome Research Institute (NHGRI) awarded a $993,446 Project Grant under the Human Genome Research Federal Grant Program (CFDA 93.172) to the Sloan-Kettering Institute for Cancer Research. The 5-year grant, commencing on May 1, 2025, aims to develop statistical and machine learning approaches that connect human genetics data with single-cell omics data to improve the understanding of the genetic architecture underlying complex diseases. Key goals include decoding the...
- Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded $789,739 to the Sloan-Kettering Institute for Cancer Research on September 19, 2025, under the Human Genome Research program (CFDA 93.172) to develop innovative approaches for engineering transcriptional states in fibroblasts and other differentiated cell types through September 2029. The award supports the transformation of Perturb-seq into a systematic platform for rationally reconstructing diverse...
- Federal Project Grant Award Summary Carnegie Mellon University received a $2.26 million Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded June 1, 2026, through May 31, 2030. The award supports the development of advanced computational methods to integrate multi-modal functional genomics data with genome-wide association studies (GWAS) findings to elucidate disease mechanisms. The research addresses current...
New York University School of Medicine received a $466,125 Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), with an award date of May 18, 2026 and completion deadline of April 30, 2028. The grant supports research developing a novel synthetic regulatory genomics approach to characterize regulatory function of genomic sequences across vertebrate species using the BIG-IN (Biomolecular In situ Genome Intervention) genome engineering technology. The research delivers two primary products: (1) functional analysis of large genomic loci (up to 160 kilobases) by replacing orthologous mouse sequences with those from five vertebrate species in mouse embryonic stem cells; and (2) combinatorial assessment of candidate enhancer sequence pairs (~1 kilobase each) from diverse species. These deliverables generate comparative functional genomics data that enable phylogenetic analysis of regulatory DNA evolution and establish a novel methodology for direct functional assessment of human disease-relevant genomic loci, bridging the gap between basic regulatory genome science and translational clinical applications.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $466.1k | 5/22/26 |