Project Grant R21HD122154
- This Project Grant, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), funds investigator-initiated research examining the role of maternal MCM4 protein in early mammalian embryonic development. The University of Massachusetts received $157,427 in obligated funding for the project period from May 25, 2026 through April 30, 2028. The research deliverables include scientific...
- Federal Grant Award Summary The University of Massachusetts received a $478,453 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 1, 2026 through May 31, 2031. This award supports large-scale analysis of early lethal phenotypes generated through the International Mouse Phenotyping Consortium (IMPC) and Knockout Mouse Project (KOMP) initiatives. The...
- Federal Project Grant Award Summary The University of Pennsylvania received a $247,138 project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 1, 2025, through August 31, 2028. The award funds investigator-initiated research to examine the role of the KIF2C protein in regulating microtubule cytoskeleton dynamics during the oocyte-to-embryo transition in...
- Federal Project Grant Award Summary Michigan State University received a $501,659 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded June 1, 2026, with completion scheduled for February 28, 2031. The award funds investigator-initiated research to advance understanding of the molecular mechanisms underlying mammalian sperm capacitation, specifically examining the...
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded the University of Massachusetts Medical School $460,625 under the Child Health and Human Development Extramural Research program (CFDA 93.865) on June 1, 2026, with completion targeted for May 31, 2028. This project grant supports the development of prime editing therapeutics for Limb Girdle Muscular Dystrophy R9 (LGMDR9), a rare genetic disorder caused by mutations in the FKRP...
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded Massachusetts General Hospital $170,640 on August 1, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support a five-year research project examining the role of the fibroblast growth factor receptor 1 (FGFR1) signaling pathway in the intersection of reproduction and metabolism. The research will elucidate how distinct fibroblast growth...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded The Washington University a $619,913 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) effective May 15, 2026, with a completion date of March 31, 2031. The award funds investigator-initiated research examining the regulatory mechanisms of CatSper (cation channel of sperm), a sperm-specific calcium channel critical to male fertility. The...
- Federal Project Grant Award Summary Duke University received a $225,324 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 1, 2025, through August 31, 2028. The research project, titled "Understanding the Role of Mitochondrial Specialization in Early Development," delivers fundamental scientific research investigating how mitochondrial...
- Federal Grant Award Summary The University of Virginia received a $962,892 Project Grant award dated July 30, 2025, from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate membrane protein-mediated signaling mechanisms in spermiogenesis. The research focuses on elucidating the molecular and biological functions of transmembrane channel-like protein 5 (TMC5) and its essential role in...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded a $730,972 Project Grant to Massachusetts General Hospital under the Child Health and Human Development Extramural Research program (CFDA 93.865) for the period June 1, 2026 through February 28, 2031. The grant supports research to develop novel small-molecule anti-Mullerian hormone receptor 2 (AMHR2) agonists as a new class of female contraceptives. The research addresses limitations of...
Project Grant Summary The University of Massachusetts received a $436,628 Project Grant awarded on May 25, 2026, by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The project, concluding April 30, 2028, focuses on defining the dynamics and regulation of calcium/calmodulin-dependent protein kinase II (CaMKII), specifically the CaMKIIγ variant essential for mammalian egg activation. The research will deliver real-time monitoring of CaMKII kinase activity during oocyte maturation, fertilization, and early embryonic development using fluorescence resonance energy transfer (FRET) biosensors (FRESCA versions). The project's primary products include enhanced FRET-based biosensor technology to track CaMKII activity with increased sensitivity and dynamic range, and empirical characterization of how CaMKIIγ autophosphorylation maintains kinase activity during fertilization intervals. The research will elucidate the regulation of divalent cation homeostasis in reproductive cells and embryonic development, advancing understanding of cellular calcium signaling mechanisms critical to human reproduction and early developmental processes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $436.6k | 5/20/26 |